Addition of Intrathecal Morphine for Postoperative Pain Management in Pediatric Spine Surgery: A Meta-analysis

Clinical Spine Surgery : a Spine Publication
Arif MusaGligor Gucev

Abstract

Meta-analysis. The objective of this study was to determine whether adjunctive intrathecal morphine (ITM) reduces postoperative analgesic consumption following pediatric spine surgery. Previous studies that have tested supplemental ITM to manage pain after pediatric spine surgery have been limited by small sample sizes. A comprehensive search of PubMed, Web of Science, Clinicaltrials.gov, and the Cochrane Central Register of Controlled Trials was performed for clinical trials and observational studies. Time to first analgesic demand, postoperative analgesic use, pain scores, and complication data were abstracted from each study. Mean difference (MD) and 95% confidence interval (CI) were used to compare continuous outcomes and odds ratios (OR) and 95% CI were used for dichotomous outcomes. A total of 5 studies, including 3 randomized controlled trials and 2 retrospective chart reviews, containing 636 subjects, were incorporated into meta-analysis. Subjects that were administered ITM in addition to postoperative analgesics (ITM group) were compared with those receiving postoperative analgesics only (control group). In the ITM group, time to first analgesic demand was longer (MD, 8.79; 95% CI, 4.20-13.37; P<0.001), cumulative anal...Continue Reading

References

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Citations

Aug 18, 2020·Orthopaedics & Traumatology, Surgery & Research : OTSR·Anaïs De BieSimon Bredin

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Software Mentioned

SPSS
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Clarivate Analytics

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