PMID: 2112667May 1, 1990Paper

Addition of L-glutamine to total parenteral nutrition and its effects on portal insulin and glucagon and the development of hepatic steatosis in rats

The Journal of Surgical Research
S J LiJ E Fischer

Abstract

Infusion of total parenteral nutrition (TPN) with excess carbohydrate calories leads to hepatic steatosis in rats and is associated with an elevated portal insulin/glucagon molar ratio. Previously we have shown that adding glucagon to TPN prevents and reverses hepatic steatosis in rats, possibly by increasing hepatic lipid export. It has been reported that steatosis is eliminated in rats by the addition of L-glutamine to TPN. In this study, we examined the effect of glutamine on portal insulin and glucagon levels and the development of hepatic steatosis. Adult rats (n = 19) received internal jugular catheters: Group 1 (n = 6), saline (3 cc/hr) and chow ad libitum; Group 2 (n = 7), 25% dextrose base TPN; Group 3 (n = 6), 25% dextrose base TPN with 2% glutamine. The infusion rate of TPN was 1.2 cc/100 g body wt/hr. Daily nitrogen balance was determined and at 7 days, portal venous blood was drawn for insulin and glucagon radioimmunoassay, livers were removed for histology and lipid content determination, and the small intestines were removed for mucosal protein and DNA content determination. Panlobular vacuolization of the hepatocytes was noted on histology in Group 2 (TPN) while Group 1 (chow) and Group 3 (TPN + glutamine) showe...Continue Reading

References

Jun 1, 1975·Journal of Pediatric Surgery·R J Touloukian, J H Seashore
May 1, 1988·The Journal of Surgical Research·J P Grant, P J Snyder
Nov 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·H C Sax, R H Bower
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
Sep 1, 1972·The Journal of Clinical Investigation·D M RochaR H Unger
Jun 1, 1983·Analytical Biochemistry·T R Downs, W W Wilfinger
Nov 1, 1984·The Journal of Clinical Investigation·R I HallS H Quarfordt

❮ Previous
Next ❯

Citations

Oct 12, 2000·Indian Journal of Pediatrics·B S Tomar
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D G FongA L Buchman
May 31, 2011·The Surgical Clinics of North America·Rifat Latifi
Jan 3, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·John P Grant
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J L Shaffer
Jul 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·G SpaethM Holmer
Mar 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·H TamadaA Okada
Jan 15, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·H ArndtK D Palitzsch
Mar 1, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·P PanigrahiK Horvath
Sep 17, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·M J BorelP J Flakoll
Sep 10, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·Alan Buchman
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaR M Salloum
Jan 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·S L YehP C Huang
Sep 12, 2000·Current Gastroenterology Reports·A L Buchman
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan L BuchmanJonathan Fryer
Jun 1, 1995·Journal of the American College of Nutrition·E R Briones, F L Iber
Jun 1, 1996·Journal of the American College of Nutrition·A L Buchman
Mar 15, 1994·Cancer·P D Inskip, J D Boice

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.