PMID: 2109539May 1, 1990Paper

Addition of lithium carbonate to carbamazepine: hematological and thyroid effects

The American Journal of Psychiatry
K G Kramlinger, R M Post

Abstract

In view of the increasing use of lithium-carbamazepine combination therapy for refractory psychiatric disorders, the authors assessed the clinical laboratory effects of adding lithium to carbamazepine in 23 patients with affective disorders. Lithium produced a robust reversal of carbamazepine-induced leukopenia, increasing WBCs, predominantly neutrophils, to levels significantly above placebo baseline values. The combination produced additive antithyroidal effects, resulting in greater decreases in T4 and free T4 than with carbamazepine alone; the addition of lithium was associated with the emergence of a modestly higher TSH level. The authors discuss clinical and theoretical implications of these findings.

Citations

Jan 1, 1992·Pharmacology & Toxicology·J Rybakowski
Aug 29, 1997·Psychiatry Research·R M PostT Huggins
Feb 1, 1994·Biological Psychiatry·M A OzdemirS Dündar
Apr 15, 1992·Biological Psychiatry·G HöflichR Schmidt
Mar 5, 2016·Clinical Pharmacokinetics·Patrick R Finley
Oct 17, 2007·The Psychiatric Clinics of North America·Madeleine BeckerElisabeth J Shakin Kunkel
Mar 24, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marco Mula
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·E Chalecka-Franaszek, D M Chuang
Oct 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert M Post
Feb 24, 1998·Journal of Clinical Psychopharmacology·P H Silverstone
Apr 28, 2005·Expert Review of Neurotherapeutics·Marco MulaMichael R Trimble
Jul 1, 1996·Acta Psychiatrica Scandinavica·A BocchettaM Del Zompo
Dec 2, 2005·Expert Opinion on Pharmacotherapy·Po W Wang, Terence A Ketter
Dec 22, 2009·Expert Review of Neurotherapeutics·Marco MulaFrancesco Monaco
Nov 26, 1999·European Psychiatry : the Journal of the Association of European Psychiatrists·J ValleJ L Ayuso-Mateos
Oct 1, 1991·The Journal of General Psychology·J B Murray
Dec 2, 2008·Expert Opinion on Pharmacotherapy·Marco MulaJosemir W Sander
Jul 19, 2019·Therapeutic Advances in Psychopharmacology·Niruj Agrawal, Marco Mula
May 8, 2014·ACS Chemical Neuroscience·Ahmad Nassar, Abed N Azab

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