PMID: 2499453Jan 1, 1989Paper

Addition of molecular methods to mutation studies with Drosophila melanogaster

Environmental and Molecular Mutagenesis
W R Lee

Abstract

For 80 years, Drosophila melanogaster has been used as a major tool in analyzing Mendelian genetics. By using chromosome inversions that suppress crossing over, geneticists have developed a large number of stocks for mutation analysis. These stocks permit numerous tests for specific locus mutations, lethals at multiple loci on any chromosome, chromosome exchanges, insertions, and deletions. The entire genome can be manipulated for a degree of genetic control not found in other germ-line systems. Recombinant DNA techniques now permit analysis of mutations to the nucleotide level. By combining classical genetic analysis with recombinant DNA techniques, it is possible to analyze mutations that range from chromosome aberrations and multilocus deficiencies to single nucleotide transitions.

References

Aug 9, 1988·Biochemistry·K R Tindall, T A Kunkel
Sep 25, 1987·Nucleic Acids Research·M B LoMonacoS H Chang
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E L LoechlerJ M Essigmann
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Dec 19, 1958·Science·W L RUSSELLE M KELLY
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Jul 22, 1927·Science·H J Muller

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