Addition of montelukast or salmeterol to fluticasone for protection against asthma attacks: a randomized, double-blind, multicenter study

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Jonathan IlowiteJonathan M Edelman

Abstract

For patients whose asthma is uncontrolled with low-dose inhaled corticosteroids, addition of alternative therapy instead of increasing the steroid dose is recommended by current treatment guidelines. To compare montelukast, a once-daily leukotriene receptor antagonist, and salmeterol, a twice-daily, long-acting beta-agonist, concomitantly administered with inhaled fluticasone, according to the percentage of patients without an asthma attack for 1 year. A randomized, double-blind, double-dummy, multicenter study was conducted. Adult patients with moderate-to-severe persistent asthma (ages 14-73 years) receiving inhaled fluticasone (220 microg/d) who remained symptomatic during a 4-week run-in period were randomized to the addition of salmeterol (84 microg/d) or montelukast (10 mg/d) for 48 weeks. Of the 1,473 randomized patients, 743 were randomized to montelukast and 730 to salmeterol; 1,059 patients completed the study. Eighty percent of patients in the montelukast group and 83.3% of patients in the salmeterol group remained attack free during the 48 weeks of treatment (relative risk, 1.20; 95% confidence interval, 0.96-1.49). Montelukast significantly reduced blood eosinophil counts compared with salmeterol, whereas salmetero...Continue Reading

References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 1, 1994·Journal of Clinical Epidemiology·E F JuniperL E Griffith
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·A WoolcockL A Jacques
Sep 6, 2000·Lancet·B J Lipworth
Sep 6, 2000·Lancet·I Rafi
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y TohdaS Nakajima
Nov 29, 2002·American Journal of Respiratory and Critical Care Medicine·Graeme P CurrieBrian J Lipworth
Jul 10, 2003·British Journal of Clinical Pharmacology·Erika J SimsBrian J Lipworth

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Citations

Jan 5, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Graeme P Currie, Kris McLaughlin
Nov 6, 2007·The New England Journal of Medicine·Marc Peters-Golden, William R Henderson
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·G P CurrieD K C Lee
Mar 12, 2005·BMJ : British Medical Journal·Graeme P CurrieJon G Ayres
Jul 5, 2013·American Journal of Respiratory and Critical Care Medicine·Jacob P Scott, Marc Peters-Golden
Apr 29, 2008·The Journal of Allergy and Clinical Immunology·Nathan RabinovitchErwin W Gelfand
Feb 5, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C S Ulrik, Z Diamant
Dec 20, 2013·Expert Opinion on Pharmacotherapy·Hiroto Matsuse, Shigeru Kohno
Jul 23, 2011·Expert Opinion on Pharmacotherapy·Salima AmlaniRichard Andrew McIvor
Apr 23, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Alberto PapiSanjeeva Dissanayake
May 10, 2005·Respiratory Medicine·Graeme P CurrieAndrew M Wilson
Jul 1, 2006·Expert Review of Clinical Immunology·Graeme P Currie
Sep 1, 2005·Expert Review of Clinical Immunology·Leif Bjermer
Nov 26, 2015·The Cochrane Database of Systematic Reviews·Bhupendrasinh F ChauhanFrancine M Ducharme
Oct 4, 2013·The Cochrane Database of Systematic Reviews·Bhupendrasinh F ChauhanFrancine M Ducharme
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Christopher J CatesMontse Ferrer
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Christopher J CatesSamuel Waterson
Apr 27, 2007·Pharmacogenetics and Genomics·Michael KlotsmanWayne H Anderson
May 18, 2012·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme
Jan 25, 2014·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme
Aug 31, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Keisaku FujimotoKeishi Kubo

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