PMID: 2100983Aug 1, 1990Paper

Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations. A randomized prospective study

Annals of Surgery
D J SchoetzM C Veidenheimer

Abstract

The efficacy of cefoxitin, a perioperative parenteral antibiotic, combined with mechanical bowel preparation and oral antibiotics to prevent wound infections and other septic complications in patients undergoing elective colorectal operations, was examined in a prospective randomized study. All 197 patients who completed the study received mechanical bowel preparation and oral neomycin/erythromycin base. In addition a perioperative parenteral antibiotic was given in three divided doses to 101 patients. The other 96 patients received no parenteral antibiotics. The overall incidence of intra-abdominal septic complications was 7.3% (7 of 96) in the control group (no cefoxitin) and 5% (5 of 101) in the treatment group (cefoxitin). This difference was not statistically significant. The incidence of abdominal wound infection was 14.6% in the control group and 5% in the treatment group, a statistically significant difference (p = 0.02). The addition of perioperative parenteral cefoxitin greatly reduced the incidence of wound infections in patients undergoing elective colorectal operations who had been prepared with mechanical bowel cleansing and oral antimicrobial agents.

Citations

Oct 13, 2001·Diseases of the Colon and Rectum·O ZmoraS D Wexner
Apr 15, 2004·Annals of Surgery·Robert L SmithEugene F Foley
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Jun 29, 2016·Langenbeck's Archives of Surgery·Donald E Fry
Apr 12, 2008·World Journal of Surgery·Takatoshi NakamuraMasahiko Watanabe
Feb 18, 2016·Surgical Infections·Donald E Fry
Oct 7, 2005·Expert Review of Anti-infective Therapy·Francesca RoveraRenzo Dionigi
Dec 25, 2008·Annals of Surgery·Jensen T PoonOswens S H Lo
Aug 27, 2010·Annals of Surgery·Michael J EnglesbeDarrell A Campbell
Oct 29, 2015·International Journal of Colorectal Disease·Derek B HennesseyKenneth Mealy
Mar 13, 2018·Inflammatory Bowel Diseases·Igors IesalnieksChristina Hackl
Mar 31, 2016·Surgical Infections·Takatoshi NakamuraMasahiko Watanabe
Feb 1, 2020·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Takatoshi NakamuraMasahiko Watanabe
Apr 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A J MangramW R Jarvis
Nov 11, 1999·Quality in Health Care : QHC·A M Glenny, F Song
Sep 1, 1992·Current Problems in Surgery·S H Dougherty, R L Simmons
Mar 25, 2011·American Journal of Surgery·Donald E Fry

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