Addition of Primary Metastatic Site on Bone, Brain, and Liver to IMDC Criteria in Patients With Metastatic Renal Cell Carcinoma: A Validation Study.

Clinical Genitourinary Cancer
Francesco MassariLaurence Albiges

Abstract

The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria have been largely adopted in clinical practice. In a recent retrospective study, we assessed that the addition of the first site of metastatic disease to brain, bone, and liver improves prognostic stratification of patients with metastatic renal cell carcinoma (mRCC). Here, we performed an external validation in patients with mRCC. Our aim was to evaluate if the addition of a new independent variable could improve IMDC prognosis prediction and reduce heterogeneity within risk categories. We selected all 1073 patients treated at a single institution for mRCC and included in the Institute Gustave Roussy Renal Cell Carcinoma database. All patients included received at least 1 line of targeted therapy or immune checkpoint inhibitors. Univariate and multivariate analyses (Cox regression model) were performed. Bootstrap validation of the final model was also carried out for internal validation. The IMDC modified classification was defined by the addition of the seventh variable, and we defined the modified IMDC good-risk criteria as 0 risks, intermediate-risk as 1 to 2 risks, and poor-risk as 3 or more risks. The presence of brain, bone, and/or live...Continue Reading

References

Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel Y C HengToni K Choueiri
Jan 26, 2017·The New England Journal of Medicine·Toni K Choueiri, Robert J Motzer
Feb 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toni K ChoueiriMichael J Morris
Mar 22, 2018·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 214 Investigators
Apr 17, 2018·Cell·Samra TurajlicUNKNOWN TRACERx Renal Consortium
Sep 2, 2018·Cancer Immunology, Immunotherapy : CII·Sabine SchmidMartin Früh
Jun 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronan FlippotLaurence Albiges
Jun 24, 2019·Clinical Genitourinary Cancer·Annelies VerbiestBenoit Beuselinck
Jul 31, 2019·Oncotarget·Fiorella RuattaLisa Derosa
Sep 15, 2019·Clinical Genitourinary Cancer·Alfredo Suarez-SarmientoBrian Shuch
Nov 2, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filippo G Dall'OlioFrancesco Massari

❮ Previous
Next ❯

Citations

Dec 9, 2020·Expert Review of Anticancer Therapy·Melissa BersanelliMimma Rizzo
Nov 21, 2020·Biology Direct·Ivana CelardoIvano Amelio
Feb 22, 2021·Clinical Genitourinary Cancer·James J Hsieh
May 1, 2021·Journal of Clinical Medicine·Angelica PetrilloBruno Daniele
Aug 19, 2021·Expert Opinion on Pharmacotherapy·Andrea MarchettiMatteo Santoni
Sep 1, 2021·JCO Clinical Cancer Informatics·Kevin SheeAnobel Y Odisho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.