Addition of rituximab to chop does not increase the risk of cardiotoxicity in patients with non-Hodgkin's lymphoma.

Medical Oncology
Saadettin KilickapIbrahim Barista

Abstract

The addition of rituximab to doxorubicin-containing standard chemotherapy significantly improves response to therapy and reduces the risk of death in B-cell non-Hodgkin's lymphoma (NHL) patients. However, the impact of this approach on doxorubicin-induced cardiotoxicity has not been elucidated. Patients who had been planned to receive CHOP or rituximab plus CHOP (R-CHOP) combination chemotherapy with a diagnosis of NHL were included in the study. In all patients, systolic and diastolic parameters were measured by using conventional and pulsed-wave tissue Doppler echocardiography, which is more sensitive than conventional lead-dependent techniques, both before and in the sixth month of therapy. There were 28 (M/F; 14/14) patients on CHOP and 33 (M/F; 16/17) patients on R-CHOP. Median age in CHOP and R-CHOP was 49 and 50 years (P = 0.44), respectively. Cumulative doxorubicin doses were 280 and 286 mg/m(2) on CHOP and R-CHOP (P = 0.65), respectively. None of the patients developed clinically evident congestive heart failure. Parameters of systolic function such as LVEF and FS did not significantly change in any patients. In both arms, tissue Doppler parameters of diastolic function such as lateral E and septal E velocity of mitral...Continue Reading

References

Feb 1, 1979·Cancer·M K AliC C Shullenberger
Nov 1, 1979·Annals of Internal Medicine·D D Von HoffF M Muggia
Sep 1, 1976·Cancer Treatment Reviews·L Lenaz, J A Page
Sep 15, 1987·Cancer·J S SteinbergA M Ross
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Feb 1, 1993·The American Journal of Medicine·K R Hande, G C Garrow
Jul 1, 1996·Annals of Internal Medicine·K ShanJ B Young
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonJ M Sorensen
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinB K Dallaire
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C ByrdC A White
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S CzuczmanC Varns
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E R Knell, C A Presant
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C LimP Tan
Mar 9, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M ForanT A Lister
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M VoseR I Fisher
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Apr 6, 2004·Leukemia & Lymphoma·V GarypidouS Theodoridou
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Myron S CzuczmanAntonio J Grillo-López
Mar 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S KilickapG Tekuzman
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FeugierB Coiffier
May 10, 2005·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Saadettin KilickapIbrahim Barista
Aug 2, 2005·Cancer Treatment Reviews·Eva Kimby
Apr 3, 2007·Southern Medical Journal·Saadettin KilickapGulten Tekuzman

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Citations

Aug 19, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Manabu MinamiHisanori Horiuchi
Mar 4, 2015·BMJ Case Reports·Kien Hoe NgPascale Gruber
Jul 16, 2014·Journal of Medical Case Reports·Figen AtalayAylin Ozsancak Ugurlu
Jul 14, 2012·Expert Opinion on Drug Safety·Carla MinoiaAttilio Guarini
Jun 2, 2016·International Journal of Hematology·Shunichiro YasudaTetsuya Fukuda
Apr 22, 2011·Expert Review of Cardiovascular Therapy·Syed Wamique YusufJean-Bernard Durand
Jan 4, 2015·Transplantation Reviews·Philip S MacklinSimon R Knight
Dec 15, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sehun LeeWookjang Seo
Jan 5, 2014·Journal of Clinical Pharmacy and Therapeutics·S LimatE Deconinck
Jun 22, 2013·European Journal of Haematology·Louise Man, Ranjit K Goudar
May 11, 2017·Journal of Renal Injury Prevention·Wisit CheungpasitpornFernando C Fervenza
May 28, 2019·Oncology Research and Treatment·Muhammet Gurdogan, Ugur Ozkan

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