Addition of silylated nucleophiles to α-oxoketenes

Chemical Communications : Chem Comm
Yohan DudognonThierry Constantieux

Abstract

A general evaluation of silylated nucleophiles to intercept transient α-oxoketenes generated by microwave-assisted Wolff rearrangement of 2-diazo-1,3-dicarbonyl compounds is presented. Original scaffolds and synthetic intermediates are accessed in a rapid, efficient and easy-to-handle way. Mechanistic studies by DFT calculations and some post-functionalizations are discussed.

References

Jul 19, 2002·Chemical Society Reviews·L Frances van StadenDavid J Ager
Feb 27, 2003·Journal of the American Chemical Society·Lewis N Mander, Matthew M McLachlan
Feb 20, 2004·Journal of the American Chemical Society·Paul T O'SullivanAndrew B Holmes
Feb 9, 2007·Organic Letters·Lifeng Wan, Marcus A Tius
Jun 3, 2009·The Journal of Organic Chemistry·Eline M Basílio JankeKlaus Weisz
Nov 4, 2011·Chemical Society Reviews·Hannah F SoreDavid R Spring
Jun 26, 2012·Chemistry : a European Journal·Kishor MohananJean Rodriguez
Dec 4, 2012·Chemistry : a European Journal·Markus HornArmin R Ofial
Jul 25, 2013·Angewandte Chemie·Jun-ichi Matsuo, Masahiro Murakami
Mar 19, 2014·Chemical Society Reviews·Paul von Ragué SchleyerIsrael Fernández
Aug 19, 2015·Chemical Reviews·Alan FordM Anthony McKervey

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