Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis.

Gastroenterology
Juan G AbraldesBLEPS Study Group

Abstract

The combination of β-blockers and band ligation is the standard approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid-lowering drug simvastatin decreases portal pressure, improves hepatocellular function, and might reduce liver fibrosis. We assessed whether adding simvastatin to standard therapy could reduce rebleeding and death after variceal bleeding in patients with cirrhosis. We performed a multicenter, double-blind, parallel trial of 158 patients with cirrhosis receiving standard prophylaxis to prevent rebleeding (a β-blocker and band ligation) in Spain from October 2010 through October 2013. Within 10 days of bleeding, subjects were randomly assigned, but stratified by Child-Pugh class of A or B vs C, to groups given simvastatin (20 mg/d the first 15 days, 40 mg/d thereafter; n = 69) or placebo (n = 78). Patients were followed for as long as 24 months. The primary end point was a composite of rebleeding and death, and main secondary end points were the individual components of the composite (death and rebleeding). The primary end point was met by 30 of 78 patients in the placebo group and 22 of 69 in the simvastatin group (P = .423). Seventeen patients in the placebo group died (22%...Continue Reading

Citations

Oct 13, 2017·Alimentary Pharmacology & Therapeutics·N Hansi, M J Williams
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert SchierwagenJonel Trebicka
Feb 15, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William Carey
Feb 15, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga Chalasani, UNKNOWN Writing Group for the AASLD NAFLD Practice Gudiance
Jul 12, 2018·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Nov 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elliot B TapperGrace L Su
Oct 6, 2017·The American Journal of Gastroenterology·Jennifer C Price, Phyllis C Tien
Feb 6, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Liangshuo HuJianhua Wang
Oct 16, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G AbraldesGuadalupe Garcia-Tsao
Jan 17, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Diana HideJordi Gracia-Sancho
Jul 4, 2019·The New England Journal of Medicine·Silvestre R Duran, Robert D B Jaquiss
Nov 11, 2017·BMC Medicine·Annalisa Berzigotti
Jan 26, 2018·Digestive Diseases and Sciences·Gyorgy Baffy
Feb 28, 2020·Clinical Liver Disease·Prashanth Francis, Lisa Forman
Sep 7, 2019·European Journal of Gastroenterology & Hepatology·Dalia Morales-ArraezManuel Hernández-Guerra
Mar 7, 2020·Gut·Jaime BoschJuan G Abraldes
Feb 23, 2020·The American Journal of Gastroenterology·Rajan VijayaraghavanShiv K Sarin
Aug 18, 2017·Archives of Disease in Childhood·Tassos GrammatikopoulosAnil Dhawan
Mar 21, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu-Ming ChangChing-Liang Lu
Jan 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincenzo La MuraJaime Bosch
Feb 28, 2017·Frontiers in Medicine·Anabel Fernández-Iglesias, Jordi Gracia-Sancho
May 26, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emmanuel A Tsochatzis, Jaime Bosch
May 24, 2017·Gastroenterology Report·Ihteshamul Haq, Dhiraj Tripathi
Oct 5, 2017·Arquivos De Gastroenterologia·Paulo Lisboa BittencourtEdmundo Pessoa Lopes
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dana D ByrneVincent Lo Re
May 22, 2018·F1000Research·Tilman SauerbruchJonel Trebicka
Feb 27, 2020·Expert Opinion on Emerging Drugs·Juan P TrivellaAndres F Carrion
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoJaime Bosch
Jul 29, 2016·World Journal of Gastroenterology : WJG·Martin JanickoPeter Jarcuska
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Felix BrunnerJaime Bosch
Nov 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu-Ming ChangChing-Liang Lu
Jul 22, 2018·Nature Reviews. Gastroenterology & Hepatology·Mauro Bernardi, Paolo Caraceni
Dec 7, 2018·Therapeutic Advances in Gastroenterology·Marina VilasecaJordi Gracia-Sancho
Jul 10, 2019·F1000Research·Alberto Zanetto, Guadalupe Garcia-Tsao
Mar 8, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G Abraldes, Kelly W Burak

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