Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation

Cytotherapy
Chun K K MaDavid J Gottlieb

Abstract

Virus-specific T-cell immunotherapy is emerging as a promising management strategy for virus infections in patients after hematopoietic stem cell transplant (HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T cells prophylactically after HSCT. Donor-derived cytomegalovirus (CMV)-, Epstein-Barr virus (EBV)-, adenoviral- and varicella zoster virus (VZV)-specific T cells were generated in a single culture and administered to HSCT patients at a dose of 2 × 10(7)/m(2) virus-specific T cells at a median of 63 days post-transplant. Patients were monitored for 12 months for evidence of viral reactivation and graft-versus-host disease. There was no acute infusion-related toxicity. Six patients developed CMV reactivation after T-cell infusion with a median peak CMV DNA titer of 600 copies per milliliter, and 1 received CMV-specific pharmacotherapy post-infusion. No EBV, adenoviral or VZV reactivation or disease was reported. Using interferon-γ Elispot analysis on post-infusion samples, we identified anti-viral immunity against all viruses including VZV. Three patients (30%) developed grade II-IV acute graft-versus-host disease. This is the first description of the use of a multi-virus-specific T-cell...Continue Reading

References

Sep 15, 2000·Journal of Immunological Methods·P PalaP J Openshaw
Feb 24, 2001·Journal of Clinical Pathology·V C Emery
Jun 3, 2004·Human Immunology·Holger Hebart, Hermann Einsele
Oct 7, 2005·Journal of Clinical Microbiology·C J McIverW D Rawlinson
Apr 1, 2006·Pediatric Transplantation·Maria Luisa MelziBruno Gridelli
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kenneth MicklethwaiteDavid Gottlieb
Jul 9, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ulrike GerdemannAnn M Leen
Dec 16, 2011·Journal of Clinical Microbiology·Seanne P BuckwalterBobbi S Pritt
Jun 27, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joshua J Augustine, Donald E Hricik
Jul 31, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Cinja SukdolakBritta Eiz-Vesper
Dec 3, 2013·Experimental Gerontology·Graham Pawelec
Jun 27, 2014·Science Translational Medicine·Anastasia PapadopoulouAnn M Leen

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Citations

May 22, 2016·Blood·Catherine M Bollard, Helen E Heslop
Jun 20, 2017·The Journal of Clinical Investigation·Claire Roddie, Karl S Peggs
Oct 9, 2019·Current Opinion in Oncology·Gaurav Sutrave, David J Gottlieb
Oct 7, 2017·Current Opinion in Infectious Diseases·Gloria Castellano-GonzalezDavid Gottlieb
Jan 17, 2020·Blood·Michael D Keller, Catherine M Bollard
Oct 28, 2017·Frontiers in Immunology·Amy Houghtelin, Catherine M Bollard
Jun 23, 2019·Current Hematologic Malignancy Reports·Wei JiangEmily Blyth
Oct 4, 2018·Current Opinion in Hematology·Edoardo MiglioriPawel Muranski
Nov 30, 2016·Frontiers in Immunology·Monica ReisAnne Richter
Oct 13, 2020·Frontiers in Immunology·Francesca CompagnoPatrizia Comoli
Feb 9, 2021·Frontiers in Immunology·Claudio AnnaloroFrancesco Onida
Nov 13, 2020·Frontiers in Immunology·Sabrina BassoPatrizia Comoli
May 1, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amanda OlsonKatayoun Rezvani
Jul 3, 2021·Journal of Fungi·Georgios KaravalakisAnastasia Papadopoulou

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