Additional benefit of using a risk-based selection for prostate biopsy: an analysis of biopsy complications in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer

BJU International
Peter K ChiuMonique J Roobol

Abstract

To investigate biopsy complications and hospital admissions that could be reduced by the use of European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculators. All biopsies performed in the Rotterdam section of the ERSPC between 1993 and 2015 were included. Biopsy complications and hospital admission data were prospectively recorded in questionnaires that were completed 2 weeks after biopsy. The ERSPC risk calculators 3 (RC3) and 4 (RC4) were applied to men attending the first and subsequent rounds of screening, respectively. Applying the predefined RC3/4 probability thresholds for prostate cancer (PCa) risk of ≥12.5% and high-grade PCa risk ≥3%, we assessed the number of complications, admissions and costs that could be reduced by avoiding biopsies in men below these thresholds. A total of 10 747 biopsies with complete questionnaires were included. For these biopsies a complication rate of 67.9% (7294/10 747), a post-biopsy fever rate of 3.9% (424/10747) and a hospital admission rate of 0.9% (92/10747) were recorded. The fever rate was found to be static over the years, but the hospital admission rate tripled from 0.6% (1993-1996) to 2.1% (2009-2015). Among 7704 biopsies which fit the criteria for RC3 or R...Continue Reading

References

Sep 8, 2009·European Urology·Monique J RoobolFritz H Schröder
Dec 18, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heidi A van VugtEwout W Steyerberg
Aug 25, 2011·European Urology·Stacy LoebFritz H Schroder
Sep 29, 2011·The Journal of Urology·Stacy LoebEdward M Schaeffer
Mar 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heidi A van VugtMonique J Roobol
Jun 22, 2013·European Urology·Stacy LoebYair Lotan
May 13, 2014·The Journal of Urology·Karl-Johan LundströmAnna Bill-Axelson
Sep 27, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Eleni AnastasiadisMark Emberton
Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma
Aug 21, 2016·European Urology·Marco BorghesiStacy Loeb

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Citations

Jan 11, 2019·Journal of Magnetic Resonance Imaging : JMRI·Vinay PrabhuStella K Kang
Mar 16, 2019·Der Urologe. Ausg. A·J Lakes, C Arsov
Sep 25, 2018·Journal of Radiation Research·Hidetaka ArimuraMasahiro Yamada

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