Additional Common Bean in the Diet of Malawian Children Does Not Affect Linear Growth, but Reduces Intestinal Permeability

The Journal of Nutrition
Sophia AgapovaMark J Manary

Abstract

Chronic malnutrition, as manifested by linear growth faltering, is pervasive among rural African children. Improvements in complementary feeding may decrease the burden of environmental enteric dysfunction (EED) and thus improve growth in children during the critical first 1000 d of development. We tested the hypothesis that systematically including common bean or cowpea into complementary feeding would reduce EED and growth faltering among children in rural Malawi. This was a double-blind clinical trial in which children 12-23 mo of age were randomly assigned to receive complementary feeding with 1 of 3 foods: roasted cowpea or common bean flour, or an isoenergetic amount of corn-soy blend as a control food for 48 wk. Children aged 12-23 mo received 155 kcal/d and thereafter until 35 mo received 200 kcal/d. The primary outcomes were change in length-for-age z score (LAZ) and improvements in a biomarker of EED, the percentage of lactulose (%L) excreted as part of the lactulose:mannitol dual-sugar absorption test. Anthropometric measurements and urinary %L excretion were compared between the 2 intervention groups and the control group separately with the use of linear mixed model analyses for repeated measures. A total of 331 ch...Continue Reading

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Citations

Mar 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·David R Brewster
Feb 15, 2020·PLoS Neglected Tropical Diseases·Ethan K GoughUNKNOWN Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team
Jun 16, 2018·The Journal of Nutrition·Reginald LeeMark J Manary
Apr 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·Yankho KaimilaMark J Manary
Dec 19, 2018·Journal of Pediatric Gastroenterology and Nutrition·Yankho KaimilaMark J Manary

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