Additional Diagnostic Value of Growth Differentiation Factor-15 (GDF-15) to N-Terminal B-Type Natriuretic Peptide (NT-proBNP) in Patients with Different Stages of Heart Failure

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jiao LiXin Qi

Abstract

BACKGROUND Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. The purpose of this study was to explore the diagnostic value of plasma GDF-15 levels in different stages of heart failure (HF) and to assess the relationship with ventricular remodeling. MATERIAL AND METHODS We enrolled 219 HF patients from the Department of Cardiology in Tianjin Union Medical Center as the HF group and 32 healthy subjects as the control group. Circulating GDF-15, NT-proBNP, procollagen I C-terminal propeptide (PICP), and N-terminal procollagen III propeptide (PIIINP) levels were measured using ELISA. Associations between GDF-15 and clinical indicators in cardiac remodeling were assessed using receiver operating characteristic (ROC) curves and Spearman correlation. All the patients were followed up for 1 year. RESULTS The level of plasma GDF-15 in HF patients was higher than in the control group (P<0.05) and increased with higher ACCF/AHA and NYHA classification (P<0.05). Patients with HFrEF had higher GDF-15 levels compared to patients with HFmrEF (P<0.05). GDF-15 and left ventricular mass index (LVMI) were significantly increased as early as the pre-clinical HF stage. Also, GDF-15 levels were positively corre...Continue Reading

Citations

May 12, 2019·Critical Reviews in Clinical Laboratory Sciences·Stéphanie DesmedtMarijn M Speeckaert
Jul 7, 2020·Disease Markers·Alexander E Berezin, Alexander A Berezin
May 20, 2020·ESC Heart Failure·Marian WesselingSaskia C A de Jager
Jun 30, 2019·Journal of Clinical Medicine·Daniel DalosMichael Sponder
Jan 10, 2021·Journal of Clinical Medicine·Marina de Cos GomezEmilio Rodrigo Calabia
Feb 11, 2021·Arquivos brasileiros de cardiologia·Bruna Miers MayLuis Eduardo Rohde
Jul 11, 2020·KI Reports·Nathan R SteinUNKNOWN CRIC Study Investigators
Aug 28, 2021·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely
Nov 17, 2021·Biomarkers in Medicine·Susanne BauerCarsten Jungbauer

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.