PMID: 6978968Mar 1, 1982Paper

Additional factor XII (Hageman factor) deficiency in hemophilia A and in von Willebrand syndrome

Klinische Wochenschrift
M BarthelsH E Karges

Abstract

Factor XII plasma levels were investigated with several methods in patients with hemophilia A and B and von Willebrand syndrome. There seem to be some families with hemophilia A or von Willebrand syndrome, who have an additional, congenital, partial lack of factor XII (Hageman factor). The mode of inheritance is independent of the other coagulation disorder. Frequently, the first indication of an additional factor XII deficiency is the disproportionate prolongation of the activated partial thromboplastin time (PTT) as regards the factor VIII level. The average factor XII level in patients with hemophilia A and von Willebrand syndrome is significantly lower than in normal subjects or patients with hemophilia B. It cannot be excluded that the frequently low levels of factor XII in patients with severe hemophilia are acquired and probably due to liver cell damage.

References

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Citations

Nov 2, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E AsatianiUNKNOWN Directors of the Comprehensive Hemophilia Treatment Centers in Region III
May 29, 2020·Equine Veterinary Journal·Anna R DahlgrenCarrie J Finno
Feb 1, 1992·American Journal of Hematology·T MatsushitaH Saito

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