Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype

The Journal of Nutritional Biochemistry
Jean HungMarie Caudill

Abstract

The effectiveness of additional food folate in improving folate status in humans is uncertain particularly in people with the common genetic variant (677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To examine the effect of a doubling of food folate consumption on folate status response variables, women (n=32; 18-46 years) with the MTHFR 677 CC or TT genotype consumed either 400 (n=15; 7 CC and 8 TT) or 800 (n=17; 8 CC and 9 TT) microg/day of dietary folate equivalents (DFE) derived exclusively from naturally occurring food folate for 12 weeks. A repeated measures two-factor ANOVA was used to examine the effect of the dietary treatment, the MTHFR C677T genotype and their interactions on serum folate, RBC folate and plasma total homocysteine (tHcy) during the last 3 weeks of the study. Consumption of 800 microg DFE/day resulted in serum folate concentrations that were 67% (P=.005) higher than consumption of 400 microg DFE/day (18.6+/-2.9 vs. 31.0+/-2.7 nmol/L, respectively) and RBC folate concentrations that were 33% (P=.001) higher (1172+/-75 vs. 1559+/-70 nmol/L, respectively). Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR ...Continue Reading

References

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Jan 14, 1998·European Journal of Clinical Nutrition·A S Truswell, S Kounnavong
May 15, 2001·Journal of the American College of Nutrition·M A CaudillE A Cogger
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Citations

Apr 7, 2012·Food & Nutrition Research·Maria de Lourdes Samaniego-VaeskenGregorio Varela-Moreiras
Mar 12, 2010·The American Journal of Clinical Nutrition·Marie A Caudill
May 23, 2008·The Journal of Nutritional Biochemistry·Christian M AbratteMarie A Caudill
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R GranellJ Henderson
Nov 11, 2017·Journal of Personalized Medicine·Claudia Ojeda-GranadosSonia Roman
Apr 28, 2018·Journal of the American College of Nutrition·Marina Ramalho RibeiroMaria José de Carvalho Costa
Feb 20, 2009·The American Journal of Clinical Nutrition·Julie RobitailleQuanhe Yang
Mar 14, 2013·Journal of Perinatal Medicine·Rima ObeidKlaus Pietrzik

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