PMID: 3321053Dec 1, 1987Paper

Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl

Proceedings of the National Academy of Sciences of the United States of America
K StrebhardtH Rübsamen-Waigmann

Abstract

We report the isolation and nucleotide sequence of a 3.7-kilobase (kb) cDNA clone from chicken spleen corresponding to a previously undescribed member of the src family of protooncogenes. It encodes a protein with a C-terminal domain related to the src family of protein-tyrosine kinases (EC 2.7.1.112) and, among these, has most significant homology to the lck gene isolated from a murine leukemia virus-induced thymoma cell line. The gene is therefore referred to as c-tkl for cellular tyrosine kinase related to lck. Analysis of genomic DNA reveals that c-tkl is a chromosomal locus distinct from c-src and c-lck. Furthermore, the size of c-tkl mRNA as well as its pattern of expression indicates that it is not the chicken homologue of lck but a different gene. A 3.8-kb transcript of the c-tkl gene, identical to the size determined for c-src mRNA, was observed in cultured chicken embryo fibroblasts and in chicken spleen and brain. In contrast, detection of a definite c-src mRNA signal with mRNA from spleen was not possible under the hybridization conditions employed when the 5' end of v-src was used as the probe, and none of the 11 clones obtained from the cDNA library corresponded to a c-src transcript. Thus previous studies of c-sr...Continue Reading

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Citations

Feb 1, 1989·Biochimica Et Biophysica Acta·R M PerlmutterK M Abraham
Jul 1, 1995·Differentiation; Research in Biological Diversity·M G AchenW Risau
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T MustelinA Altman
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y YamanashiK Toyoshima
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U HoltrichH Rübsamen-Waigmann
Jan 1, 1989·The Journal of Cell Biology·V M WaseniusV P Lehto
Dec 9, 1988·Nucleic Acids Research·T SoussiP May
Aug 15, 1992·European Journal of Biochemistry·T GärtnerH Rübsamen-Waigmann
Sep 1, 1991·Critical Reviews in Oncology/hematology·S Demczuk
Sep 17, 2008·Molecular and Cellular Biology·Lin-Yu LuJunjie Chen
Jan 1, 1989·Molecular and Cellular Biology·T J LeyK C Robbins
Sep 1, 1997·Molecular and Cellular Biology·S BartlC Seiser
Aug 1, 1988·Molecular and Cellular Biology·A MacAuley, J A Cooper
Mar 1, 1992·Molecular and Cellular Biology·L M ChowA Veillette

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