PMID: 3751287Jul 1, 1986Paper

Additional methylation at the N(2)-position of the cap of 26S Semliki Forest virus late mRNA and initiation of translation

Virus Research
L P van DuijnH O Voorma

Abstract

Cap analysis of the late 26S Semliki Forest viral mRNA reveals that almost 30% of the caps possess both a methyl group at the N(7)-position and one at the N(2)-position. We have compared the degree of methylation of the caps of polysomal and non-polysomal 26S mRNA in order to check whether this feature is responsible for its translation late in infection. It was found that extra methyl groups on the caps cause a lower rate of initiation. Polysomal 26S mRNA contained less m2,7G- and m2,2,7G-caps than free 26S. The cap analog m2,2,7Gp was slightly less inhibitory than m7Gp in an in vitro translation system.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·N SonenbergA J Shatkin

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Citations

May 20, 1999·Antiviral Research·A LampioL Kääriäinen
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Venkat S R K Yedavalli, Kuan-Teh Jeang
Oct 30, 2008·Nucleic Acids Research·Augusto Simoes-BarbosaPatricia J Johnson
Feb 17, 2009·RNA·Delphine BenarrochStewart Shuman
Jul 31, 2012·Antiviral Research·François FerronBruno Canard
Feb 4, 2014·The Journal of General Virology·Hongping DongPei-Yong Shi
Mar 2, 2011·RNA Biology·Venkat S R K Yedavalli, Kuan-Teh Jeang
Jul 28, 2005·The Journal of Biological Chemistry·Stéphane Hausmann, Stewart Shuman
Nov 7, 2019·Wiley Interdisciplinary Reviews. RNA·Rachel Netzband, Cara T Pager
Dec 11, 2020·Wiley Interdisciplinary Reviews. RNA·Jerry PelletierNahum Sonenberg
Apr 1, 1990·Molecular and Cellular Biology·R F Liou, T Blumenthal
Sep 1, 1994·Microbiological Reviews·J H Strauss, E G Strauss

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