Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia

NeuroImage
Ignacio MataBenedicto Crespo-Facorro

Abstract

Neuregulin 1 (NRG1) and Disrupted-in-schizophrenia (DISC1) genes, which are candidate genes for schizophrenia, are implicated in brain development. We have previously reported an association between the T allele of the rs6994992 SNP within NRG1 gene and lateral ventricle (LV) enlargement in first-episode schizophrenia patients. Moreover, transgenic mice with mutant DISC1 have also been reported as showing LV enlargement. In this study, we examined the possible interactive effects of NRG1 and DISC1 on brain volumes in a sample of first-episode schizophrenia patients. Ninety-one patients experiencing their first episode of schizophrenia underwent genotyping of three SNPs within DISC1 and structural brain MRI. These results were combined with our previously reported genotypes on three SNPs within NRG1. The T/T genotype of rs2793092 SNP in DISC1 was significantly associated with increased LV volume. However, taking into account the rs6994992 SNP in the NRG1 gene, which was also associated with LV volume in a previous study, the DISC1 SNP only predicted LV enlargement among those patients carrying the T allele in the NRG1 SNP. Those patients with the "at risk" allelic combinations in both genes had LV volumes which were 48% greater ...Continue Reading

References

Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·N C AndreasenV W Swayze
May 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P Jones, R M Murray
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·I I Gottesman, J Shields
Dec 15, 1996·Schizophrenia Research·K E WardS C Schulz
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·S M Lawrie, S S Abukmeil
Jan 23, 1999·Biological Psychiatry·L D Selemon, P S Goldman-Rakic
Jan 5, 2000·The American Journal of Psychiatry·I C WrightE T Bullmore
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Dec 16, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D FannonT Sharma
Jul 27, 2001·Human Molecular Genetics·J EkelundL Peltonen
May 3, 2002·Molecular Psychiatry·J A Badner, E S Gershon
Sep 5, 2002·American Journal of Medical Genetics·Colm McDonaldRobin M Murray
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Oct 22, 2003·Molecular Psychiatry·R HashimotoD R Weinberger
Mar 23, 2004·Journal of Neurocytology·Douglas L Falls
May 27, 2004·Nature Neuroscience·Gabriel CorfasJoseph D Buxbaum
Jul 22, 2004·Nature Reviews. Genetics·Orjan Carlborg, Chris S Haley
Mar 31, 2005·Molecular and Cellular Neurosciences·N J BrandonP J Whiting
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joseph H CallicottDaniel R Weinberger
Aug 2, 2005·Neuroreport·Katherine E BurdickAnil K Malhotra
Aug 6, 2005·Schizophrenia Bulletin·Sarah TosatoDavid Collier
Mar 3, 2006·Human Molecular Genetics·Barbara K LipskaJoel E Kleinman
Mar 4, 2006·The American Journal of Psychiatry·Colm McDonaldRobin M Murray
Oct 31, 2006·Nature Neuroscience·Jeremy HallStephen M Lawrie
Nov 17, 2006·The Journal of Clinical Psychiatry·Benedicto Crespo-FacorroJosé Luis Vázquez-Barquero
Oct 4, 2007·Molecular Psychiatry·J E ChubbJ K Millar
Oct 11, 2007·Molecular Psychiatry·A M McIntoshJ Hall
Dec 15, 2007·Biological Psychology·Philip R SzeszkoAnil K Malhotra
Feb 5, 2008·Schizophrenia Research·Victor Z ChongCynthia Shannon Weickert

❮ Previous
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Citations

Jul 11, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Basant K Tiwary
Sep 1, 2011·Schizophrenia Bulletin·Madiha ShaikhElvira Bramon
May 18, 2013·BMC Medicine·Uzoezi OzomaroCharles B Nemeroff
Apr 25, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin J Schmidt, Karoly Mirnics
Apr 4, 2013·Frontiers in Biology·Pippa A ThomsonJ Kirsty Millar
Sep 3, 2013·The Journal of Nervous and Mental Disease·Vicente Molina, José A Blanco
Dec 21, 2012·Expert Review of Neurotherapeutics·Holly L RedpathJeremy Hall
Jan 31, 2013·Schizophrenia Research·Prachi KukshalB K Thelma
Jun 15, 2015·Psychiatry Research·Paula Suárez-PinillaBenedicto Crespo-Facorro
Nov 8, 2012·Expert Opinion on Therapeutic Targets·Takatoshi HikidaAkira Sawa
Apr 23, 2013·Schizophrenia Research·Barbara J DuffDouglas H R Blackwood
May 1, 2013·Neuroscience and Biobehavioral Reviews·János M RéthelyiIstván Bitter
May 21, 2014·Psychiatry Investigation·Javier Vázquez-BourgonBenedicto Crespo-Facorro
Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Nov 12, 2010·Nature·Andreas Meyer-Lindenberg
Nov 19, 2011·Nature Reviews. Neuroscience·Nicholas J Brandon, Akira Sawa
Jun 21, 2011·Journal of Neural Transmission·Yoanna Arlina KurnianingsihKang Sim

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