Additive effects of ileal secretagogues in the rat

Gastroenterology
A N Charney, H M Dansky

Abstract

Although clinical diarrhea is often caused by more than one enteropathogen, it is not known whether secretagogues have additive effects on secretion. This question was examined in anesthetized, ventilated rats by exposing the ileum to secretory agents with different mechanisms of action. Four hours after inoculation of ileal loops with either cholera toxin or saline, transport was measured during perfusion with Ringer's solution, with Ringer's solution containing Escherichia coli heat-stable enterotoxin or mannitol, or with Ringer's solution containing both heat-stable enterotoxin and mannitol. We found that heat-stable enterotoxin caused similar decrements in water absorption in loops exposed to Ringer's solution, hypertonic mannitol, cholera toxin, and cholera toxin plus mannitol. By contrast, the decrement in water transport caused by hypertonic mannitol was inversely related to the level of ongoing water transport. In addition, the electrolyte transport changes caused by each enterotoxin were preserved despite the presence of other secretory agents. These data suggest that the transport effects of secretagogues with different mechanisms of action are additive in the ileum. However, the absolute decrements in water absorptio...Continue Reading

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Citations

Mar 18, 2004·Biochimica Et Biophysica Acta·Alan N CharneyMitchell B Cohen
Jun 26, 1999·Alimentary Pharmacology & Therapeutics·P DucrotteP Denis
Oct 31, 2001·Alimentary Pharmacology & Therapeutics·M JacobR J Simpson
Mar 24, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A MaselliD Lorusso
Dec 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B MearadjiA A Masclee
Sep 14, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·K W Romański
Mar 26, 2003·Journal of Toxicology and Environmental Health. Part a·Filiz KuralaySermin Ozkal
May 1, 1993·European Journal of Clinical Investigation·K J Van ErpecumG P van Berge Henegouwen
Jul 1, 1992·Journal of Gastroenterology and Hepatology·G P YoungR H Whitehead
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·S P ChouD A Dawson
Jun 18, 2002·Journal of Cellular and Molecular Medicine·J Schlichting, U Leuschner
Dec 7, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Norberto C Chavez-TapiaMisael Uribe
Oct 18, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Tilman R RohrerEva Stierkorb

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