Additive Manufacturing of a Point-of-Care "Polypill:" Fabrication of Concept Capsules of Complex Geometry with Bespoke Release against Cardiovascular Disease

Advanced Healthcare Materials
Beatriz C PereiraMohamed A Alhnan

Abstract

Polypharmacy is often needed for the management of cardiovascular diseases and is associated with poor adherence to treatment. Hence, highly flexible and adaptable systems are in high demand to accommodate complex therapeutic regimens. A novel design approach is employed to fabricate highly modular 3D printed "polypill" capsules with bespoke release patterns for multiple drugs. Complex structures are devised using combined fused deposition modeling 3D printing aligned with hot-filling syringes. Two unibody highly modular capsule skeletons with four separate compartments are devised: i) concentric format: two external compartments for early release while two inner compartments for delayed release, or ii) parallel format: where nondissolving capsule shells with free-pass corridors and dissolution rate-limiting pores are used to achieve immediate and extended drug releases, respectively. Controlling drug release is achieved through digital manipulation of shell thickness in the concentric format or the size of the rate limiting pores in the parallel format. Target drug release profiles are achieved with variable orders and configurations, hence confirming the modular nature with capacity to accommodate therapeutics of different pr...Continue Reading

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Citations

Dec 17, 2020·Patient Preference and Adherence·Eleanna MakrisJustin M Wright
Feb 5, 2021·Science Advances·Nevena PaunovićJean-Christophe Leroux
Oct 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyan XuAbdul W Basit
Mar 5, 2021·International Journal of Pharmaceutics·Georgios K EleftheriadisDimitrios G Fatouros
Apr 9, 2021·Advanced Drug Delivery Reviews·Sedigheh BorandehJukka Seppälä
Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan
May 6, 2021·Advanced Drug Delivery Reviews·Atheer AwadAbdul W Basit
May 10, 2021·Advanced Drug Delivery Reviews·Iria Seoane-ViañoAlvaro Goyanes
Jul 10, 2021·Trends in Pharmacological Sciences·Moe ElbadawiAbdul W Basit
Aug 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brais Muñiz CastroAlvaro Goyanes
Aug 15, 2021·Advanced Drug Delivery Reviews·Dhara RaijadaNatalja Genina
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen
Sep 4, 2021·Advanced Drug Delivery Reviews·Atheer AwadAbdul W Basit
Sep 23, 2020·International Journal of Pharmaceutics·Moe ElbadawiAlvaro Goyanes

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