PMID: 3762018Aug 1, 1986Paper

Additive positive inotropic effects of milrinone, ouabain and calcium in diseased human ventricular myocardium

Klinische Wochenschrift
L BrownE Erdmann

Abstract

The interactions of milrinone, ouabain and calcium on force of contraction in isolated, contracting human papillary muscle strips were measured. Milrinone (EC50, 8 X 10(-5)M) increased force of contraction maximally by 2.8 +/- 0.8 mN at 5 X 10(-4)M; significantly less than either ouabain (1 X 10(-7)M; 4.8 +/- 0.5 mN increase) or calcium (15 mM; 6.2 +/- 0.6 mN increase). A submaximal, but not a maximal, inotropic effect of ouabain could be increased by the addition of milrinone; in contrast, both ouabain and calcium increased the maximal inotropic effect of milrinone by 1.7 +/- 0.2 mN and 2.7 +/- 0.3 mN, respectively. The combined inotropic effect of milrinone with either ouabain of 4.2 +/- 0.3 mN or calcium of 5.6 +/- 0.4 mN was not different from that with calcium or ouabain alone. We conclude that further positive inotropic effects should be expected when digitalis is given to patients with congestive heart failure who are already optimally treated with milrinone.

References

Jan 1, 1985·Journal of Cardiovascular Pharmacology·L Will-ShahabI Küttner
Mar 1, 1984·Journal of Cardiovascular Pharmacology·P K SieglC S Sweet
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
May 1, 1984·Cardiovascular Research·P T WilmshurstM M Webb-Peploe
Jun 1, 1980·Journal of Molecular and Cellular Cardiology·R W MillardA Schwartz

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Citations

Dec 1, 1991·Journal of Pharmacological Methods·R S LabowW J Keon
Dec 11, 2019·Current Pharmaceutical Biotechnology·Najah Abi-GergesAndre Ghetti

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