Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion

The Journal of Thoracic and Cardiovascular Surgery
Leo M GazoniI L Kron

Abstract

Adenosine A2A receptor activation during reperfusion improves lung ischemia-reperfusion injury. In this study we sought to determine whether pretreatment of rabbits with a potent and selective adenosine A2A receptor agonist, ATL-313, before transplantation or whether adding ATL-313 to the preservation solution results in equivalent or additional protection compared with ATL-313 added during reperfusion. An isolated, ventilated, ex vivo blood-perfused rabbit lung model was used. All groups underwent 2 hours of reperfusion after 18 hours of cold ischemia (4 degrees C). ATL-313 was administered 1 hour before ischemia intravenously, with the preservation solution, and/or during reperfusion. Both pretreatment of donor animals with ATL-313 or adding ATL-313 just during reperfusion improved pulmonary function, but significantly greater improvement was observed when pretreatment and treatment during reperfusion were combined (all P < .05). Myeloperoxidase levels, bronchoalveolar lavage tumor necrosis factor alpha levels, and pulmonary edema were all maximally decreased in the combined treatment group. The administration of an equimolar amount of the potent and highly selective adenosine 2A receptor antagonist, ZM 241385, along with ATL...Continue Reading

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Citations

Apr 23, 2009·American Journal of Respiratory and Critical Care Medicine·Vibha N Lama
Jun 30, 2009·Respiratory Research·Ashish K SharmaVictor E Laubach
Aug 1, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Amma Owusu-AnsahSolomon F Ofori-Acquah
Sep 2, 2015·The Journal of Thoracic and Cardiovascular Surgery·Cynthia E WagnerIrving L Kron
Apr 2, 2013·The Annals of Thoracic Surgery·Daniel P MulloyVictor E Laubach
Sep 5, 2012·The Journal of Thoracic and Cardiovascular Surgery·Daniel P MulloyIrving L Kron
Nov 5, 2011·The Annals of Thoracic Surgery·Abbas EmaminiaChristine L Lau
Jul 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Damien J LaParIrving L Kron
Mar 25, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joshua J FieldJoel Linden
Oct 6, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yunge ZhaoChristine L Lau
Jul 28, 2010·The Journal of Thoracic and Cardiovascular Surgery·Farshad AnvariVictor E Laubach
Apr 20, 2010·The Journal of Thoracic and Cardiovascular Surgery·Leo M GazoniVictor E Laubach
Sep 22, 2009·The Annals of Thoracic Surgery·Christine L LauJoel Linden
Mar 5, 2009·The Journal of Thoracic and Cardiovascular Surgery·Zequan YangVictor E Laubach
Feb 25, 2009·Medical Hypotheses·Stevan P TofovicOlga Rafikova
Nov 26, 2008·The Journal of Thoracic and Cardiovascular Surgery·Turner C LisleIrving L Kron
Nov 17, 2009·The Journal of Thoracic and Cardiovascular Surgery·Ashish K SharmaZequan Yang
Mar 5, 2015·Pharmacology, Biochemistry, and Behavior·Małgorzata ZygmuntJacek Sapa
Jan 13, 2016·American Journal of Respiratory and Critical Care Medicine·Ashish K SharmaVictor E Laubach
Nov 10, 2017·Current Opinion in Organ Transplantation·Eduardo Castillo-LeonPaolo Fiorina
Oct 10, 2009·Physiology·Tobias EckleHolger K Eltzschig
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Oct 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Scott YeudallVictor E Laubach
Nov 30, 2010·Expert Opinion on Therapeutic Targets·Victor E LaubachMark D Okusa
Jun 2, 2020·Frontiers in Immunology·Thomas ReschSefan Schneeberger
Mar 3, 2021·Current Opinion in Organ Transplantation·Nathan HaywoodVictor E Laubach
Mar 27, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Nathan HaywoodMark E Roeser

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