Additive Value of Integrated Backscatter IVUS for Detection of Vulnerable Plaque by Optical Frequency Domain Imaging: An Ex Vivo Autopsy Study of Human Coronary Arteries

JACC. Cardiovascular Imaging
Masataka NakanoRenu Virmani

Abstract

This study sought to evaluate the diagnostic performance of optical frequency domain imaging (OFDI) for recognition of coronary plaque morphologies and to assess additive values of integrated backscatter intravascular ultrasound (IB-IVUS) in detection of vulnerable plaque. Precise diagnosis of coronary lesions susceptible to plaque rupture and thrombosis may serve to stratify the risk of future coronary events and to make decisions for appropriate treatment of choice. Twenty-seven coronary arteries from 14 human autopsy hearts were interrogated ex vivo by OFDI and IB-IVUS. Imaged segments were sectioned at 3 mm intervals where a total of 360 pairs of cross-sectional images coregistered to histology were investigated. Overall, OFDI could depict various plaque components and structures such as fibrous tissue, sheet and nodular calcification, lipid, cholesterol crystals, and healed plaque rupture. OFDI could detect 14 of 18 thin-cap fibroatheroma (TCFA), however, the diagnostic accuracy was not high (positive predictive value [PPV] = 60.9%, κ = 0.664; area under the curve [AUC]: 0.88) mainly because of signal interference from macrophages. Further, we defined IB-IVUS-derived TCFA by recursive partitioning analysis as: 1) cross-sec...Continue Reading

References

May 1, 1997·The New England Journal of Medicine·A P BurkeR Virmani
Sep 26, 2006·American Heart Journal·Teruyoshi KumeKiyoshi Yoshida
Jun 27, 2009·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
Aug 14, 2010·JACC. Cardiovascular Imaging·Patrick DonnellyUdo Hoffmann
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
Jul 16, 2011·JACC. Cardiovascular Imaging·Roberto DilettiPatrick W Serruys
Jan 14, 2012·JACC. Cardiovascular Imaging·Masataka NakanoRenu Virmani
Apr 29, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tomasz RolederAnnapoorna S Kini
Jun 7, 2014·Circulation Research·Hector M Garcia-GarciaZahi A Fayad

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Citations

Jul 30, 2016·European Heart Journal Cardiovascular Imaging·Jing Chun TeoRenu Virmani
Jun 2, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi HondaSatoshi Yasuda
Apr 5, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christian B PoulsenRanil de Silva
May 21, 2020·Circulation Reports·Kenichiro OtsukaBrett E Bouma
Aug 1, 2020·The International Journal of Cardiovascular Imaging·Koji IsodonoHiroshi Fujita
Jul 28, 2019·Nature Reviews. Cardiology·Sho ToriiAloke V Finn
Aug 28, 2020·Frontiers in Cardiovascular Medicine·Masafumi OnoPatrick W Serruys
Apr 28, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hiroki ShibutaniIchiro Shiojima
Jul 6, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jian RenBrett E Bouma

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