Additively Manufactured Continuous Cell-Size Gradient Porous Scaffolds: Pore Characteristics, Mechanical Properties and Biological Responses In Vitro

Materials
Fei LiuZuqiang Su

Abstract

Porous scaffolds with graded open porosity combining a morphology similar to that of bone with mechanical and biological properties are becoming an attractive candidate for bone grafts. In this work, scaffolds with a continuous cell-size gradient were studied from the aspects of pore properties, mechanical properties and bio-functional properties. Using a mathematical method named triply periodic minimal surfaces (TPMS), uniform and graded scaffolds with Gyroid and Diamond units were manufactured by selective laser melting (SLM) with Ti-6Al-4V, followed by micro-computer tomography (CT) reconstruction, mechanical testing and in vitro evaluation. It was found that gradient scaffolds were preferably replicated by SLM with continuous graded changes in surface area and pore size, but their pore size should be designed to be ≥ 450 μm to ensure good interconnectivity. Both the Gyroid and Diamond structures have superior strength compared to cancellous bones, and their elastic modulus is comparable to the bones. In comparison, Gyroid exhibits better performances than Diamond in terms of the elastic modulus, ultimate strength and ductility. In vitro cell culture experiments show that the gradients provide an ideal growth environment fo...Continue Reading

References

Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
Mar 21, 2007·Biomaterials·Jia Ping LiKlaas de Groot
Mar 20, 2008·Journal of the Royal Society, Interface·Monika RumplerPeter Fratzl
Apr 1, 2008·Journal of the Mechanical Behavior of Biomedical Materials·K F LeongW Y Yeong
Jun 22, 2010·Acta Biomaterialia·Ferry P W MelchelsDirk W Grijpma
Jul 15, 2011·Biomaterials·Sebastian C KapferGerd E Schröder-Turk
Nov 28, 2012·Acta Biomaterialia·Maria B Rahmany, Mark Van Dyke
Dec 21, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Johan Van der StokHarrie Weinans
Feb 14, 2013·Annals of Biomedical Engineering·J KnychalaB G Sengers
Nov 5, 2013·Acta Biomaterialia·S M GiannitelliA Rainer
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ruben WauthleJan Schrooten
Jul 27, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Chunze YanPhilippe Young
Jul 29, 2015·Biomaterials Science·Amir A Zadpoor
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Naoya TaniguchiShuichi Matsuda
Feb 7, 2017·Journal of the Mechanical Behavior of Biomedical Materials·M SpeirsJ-P Kruth
Feb 8, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Changjun HanYusheng Shi
May 2, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Qichun RanKaiyong Cai
Jul 24, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Qichun RanKaiyong Cai
Oct 21, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Zena J WallyGwendolen C Reilly
Oct 26, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Lei YangShoufeng Yang
Feb 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinkun ShenKaiyong Cai

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Methods Mentioned

BETA
scanning electron microscopy
fluorescence microscopy
Fluorescent

Software Mentioned

Gyroid
Mimics
MATLAB
Magics
Origin
Mimics17

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