Additivity of bimatoprost or travoprost to latanoprost in glaucomatous monkey eyes

Archives of Ophthalmology
Donna J GagliusoS M Podos

Abstract

To compare the ocular hypotensive effect of the commercially available preparations of bimatoprost or travoprost added to latanoprost in monkey eyes with laser-induced unilateral glaucoma. Four monkeys with unilateral laser-induced glaucoma were used in each treatment group and received drops in the glaucomatous eye only. Intraocular pressure (IOP) was measured hourly for 6 hours, beginning at 9:30 am on day 1 (untreated baseline), days 6 and 7 (single-agent therapy), and days 13 and 14 (2-drug combination therapy). On days 2 through 7, 1 drop of the scheduled single agent was given immediately after the 9:30 am IOP measurement, and on days 8 through 14, the second scheduled drug was given 5 minutes after the first. The following 5 different dosing protocols were studied: latanoprost with bimatoprost added, bimatoprost with latanoprost added, latanoprost with travoprost added, travoprost with latanoprost added, and latanoprost with a second dose of latanoprost added. There were no statistically significant (P =.95) differences among the mean baseline IOPs in any of the 5 treatment groups. When applied as single agents, latanoprost, bimatoprost, and travoprost all produced significant (P<.05) and equivalent (P =.98) reductions i...Continue Reading

Citations

Dec 24, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sudharshan HariharanAshim K Mitra
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Louis B Cantor
Jul 18, 2015·Veterinary Ophthalmology·Jessica E McDonaldGillian J McLellan
Aug 28, 2007·British Journal of Pharmacology·D F WoodwardA H-P Krauss

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