Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy

Sarcoma
Shailaja RajPierre L Triozzi

Abstract

Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as "Coley's toxins." However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumor and immune cells in the tumor microenvironment play a crucial role in response to immunotherapy. There is a dynamic equilibrium created by the immune cells infiltrating the tumor, and this forms the basis of tumor evasion. Manipulating the intratumoral microenvironment will help overcome tumor evasion.

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Citations

Nov 22, 2019·Veterinary and Comparative Oncology·Antonella BorgattiJessica Lawrence
Mar 2, 2021·Journal of Integrative Medicine·Li-Jun LiChang-Lin Zhao
Feb 19, 2021·Frontiers in Genetics·Dongjun DaiQichun Wei
Feb 23, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Emily De LombaerdeBruno G De Geest

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