PMID: 3766145Jul 1, 1986Paper

Adenine nucleotides in cultured brain cells after exposure to methyl mercury and triethyl lead

Acta Pharmacologica Et Toxicologica
I K Grundt, A M Bakken

Abstract

To obtain more information on the biochemical background, of methyl mercury (MeHg) and triethyl lead (Et3Pb) toxicity, the doses which were needed to alter the cellular content of adenine nucleotides were compared to doses which induced morphological alterations. Three-week-old cultures of brain cells from new-born rat were incubated for 5-60 min. with 28, 16, and 8 X 10(-6) M MeHg or with 3 X 10(-6) M Et3Pb in the nutrition medium. MeHg at 28 and 16 X 10(-6) M simultaneously changed the cell shape and reduced both the cellular content of adenine nucleotides and the relative level of ATP. In cells treated with 16 X 10(-6) M MeHg, a cellular increase in inosine and hypoxanthine and an unaltered content of adenine nucleotides in the nutrition medium, points to an intracellular degradation of adenine nucleotides. Incubation with 8 X 10(-6) M MeHg during the first hour of incubation, did not change the content of adenine nucleotides, however, MeHg induced a slowly progressing degeneration of cellular extensions. 3 X 10(-6) M Et3Pb induced morphological alterations but no changes in cellular nucleotide levels. The results show that morphological alterations occur in MeHg and Et3Pb treated cultures at concentrations of the compounds ...Continue Reading

References

Apr 1, 1985·Developmental Biology·A Espinosa de los MonterosG Labourdetti
Nov 1, 1984·Toxicology and Applied Pharmacology·A AllyD R Miller
Feb 1, 1981·Experimental and Molecular Pathology·B H Choi, L W Lapham
Sep 1, 1980·Bulletin of Environmental Contamination and Toxicology·D W Gruenwedel, D Friend

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Citations

Sep 1, 1990·Journal of Neurochemistry·T Sarafian, M A Verity

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