Adeno-associated virus (AAV) vectors in cancer gene therapy

Journal of Controlled Release : Official Journal of the Controlled Release Society
Jorge L Santiago-Ortiz, David V Schaffer

Abstract

Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For cancer applications, AAV vectors have been harnessed for delivery of an extensive repertoire of transgenes to preclinical models and, more recently, clinical trials involving certain cancers. This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells. We also discuss the current status of AAV clinical development in oncology and future directions for AAV in this field.

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R M KotinK I Berns
Mar 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K I Berns, R M Linden
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·T R FlotteP L Zeitlin
Jun 13, 1998·Human Gene Therapy·J S BartlettT J McCown
Jun 16, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·M GrifmanM D Weitzman
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Qing XieMichael S Chapman
Dec 21, 2002·The Journal of Biological Chemistry·Bong Kyung ShinSamir M Hanash
May 2, 2003·Journal of Biomedicine & Biotechnology·Tracy Robson, David G. Hirst
May 3, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenfang Shi, Jeffrey S Bartlett
Sep 26, 2003·Cancer Biology & Therapy·Judah Folkman
Aug 17, 2004·Cancer Immunology, Immunotherapy : CII·Luisa NovellinoGiorgio Parmiani
Oct 9, 2004·International Journal of Cancer. Journal International Du Cancer·Xueying SunRuian Xu
Feb 22, 2005·International Journal of Cancer. Journal International Du Cancer·Niranjan YanamandraJasti S Rao
Apr 1, 2005·International Journal of Cancer. Journal International Du Cancer·Hong MaRuian Xu
Apr 19, 2005·Nature Biotechnology·Jianmin FangKarin Jooss
Jun 18, 2005·Cancer Gene Therapy·Chengwen LiRichard Jude Samulski
Nov 15, 2005·The Journal of Gene Medicine·Luca PeraboHildegard Büning
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong MaDexian Zheng
Jan 24, 2006·Nature Biotechnology·Narendra MaheshriDavid V Schaffer
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sufang WuDing Ma
Sep 22, 2006·Clinical Medicine & Research·Deanna Cross, James K Burmester
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Yuji TakeiKeiya Ozawa
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Betty LiKarin Jooss
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P Mancheño-Corvo, P Martín-Duque
Apr 6, 2007·The AAPS Journal·Xiang GaoDexi Liu

❮ Previous
Next ❯

Citations

Sep 10, 2016·Pharmaceutical Patent Analyst·Marie Stark, R Holland Cheng
Oct 7, 2016·PloS One·Martin J HicksRonald G Crystal
Jul 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tianzhuo YaoDemin Zhou
Jun 13, 2017·Expert Opinion on Biological Therapy·Antonela S AsadMarianela Candolfi
Aug 31, 2018·Journal of Cellular and Molecular Medicine·Dafei ChaiJunnian Zheng
Dec 8, 2017·Journal of Human Genetics·Shota NakadeTetsushi Sakuma
Mar 29, 2020·Journal for Immunotherapy of Cancer·Inês T SimõesFrancisco Lozano
Jul 12, 2019·Current Eye Research·Jinjing CaoChun Zhang
Jun 13, 2020·International Reviews of Immunology·Sidhant Jain, Sahil Kumar
Aug 17, 2018·Diseases·Sara ArtusiJoseph C Glorioso
Sep 27, 2018·Frontiers in Immunology·Cleo Goyvaerts, Karine Breckpot
Mar 7, 2019·Frontiers in Oncology·Johanna ReulChristian J Buchholz
Sep 12, 2019·Frontiers in Neuroscience·Christine SaleebaSimon McMullan
Sep 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mathieu BerchelPatrick Midoux
Nov 27, 2019·Cancers·Kenya KamimuraShuji Terai
Jun 27, 2020·Cancers·Aishani SachdevaIrene Chong
Dec 15, 2020·Human Gene Therapy·Motahareh Sheikh-HosseiniBabak Arjmand
Nov 27, 2020·Journal of Neuroscience Methods·Antonio LuchicchiNathan Marchant
Jan 28, 2021·Cancer Cell International·Xin XuXiaochun Zhang
Jan 22, 2021·Life Sciences·Esam Bashir Yahya, Amaal Mohammed Alqadhi
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Da SunZheng-Rong Lu
Mar 9, 2021·Advanced Nanobiomed Research·Halle LutzKe Cheng
Oct 11, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·David S OjalaDavid V Schaffer
Jan 23, 2019·Molecular Therapy Oncolytics·Jonathan A HenselSelvarangan Ponnazhagan
Mar 27, 2021·Molecular Therapy. Methods & Clinical Development·Yuan MengYing Liu
Mar 30, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenli ChenXiaochun Zhang
Apr 2, 2021·Frontiers in Molecular Neuroscience·Kaushik BanerjeeMaria G Castro
Dec 18, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·John S S ButterfieldRadoslaw Kaczmarek
Apr 30, 2021·Frontiers in Chemistry·Yan YangYi Hou
Aug 14, 2021·Frontiers in Cell and Developmental Biology·Fan ChaoGang Chen
Nov 14, 2016·ACS Biomaterials Science & Engineering·T M RobinsonJ Suh

❮ Previous
Next ❯

Related Concepts

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.