Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues

British Journal of Pharmacology
Lars M IttnerYazi D Ke

Abstract

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that presents with cognitive decline. The current understanding of underlying disease mechanisms remains incomplete. Genetically modified mouse models have been instrumental in deciphering pathomechanisms in AD. While these models were typically generated by classical transgenesis and genome editing, the use of adeno-associated viruses (AAVs) to model and investigate AD in mice, as well as to develop novel gene-therapy approaches, is emerging. Here, we reviewed literature that used AAVs to study and model AD and discuss potential gene therapy strategies.

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Citations

Aug 31, 2019·British Journal of Pharmacology·J A DuceP M Beart
Jul 22, 2019·International Journal of Molecular Sciences·Maria BerrocalAna M Mata
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Julio A Flores-CuadraMaria B Carreira
Jan 27, 2021·Annual Review of Pathology·Caitlin S LatimerThomas J Montine
Mar 9, 2021·Frontiers in Neuroscience·Mohammed Amir HusainMélanie Plourde

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