Adeno-associated virus may play a protective role against human papillomavirus-induced cervical lesions independent of HIV serostatus

International Journal of STD & AIDS
L Bueno de FreitasL C Spano

Abstract

This study investigated the prevalence of adeno-associated virus (AAV) and human papillomavirus (HPV) DNA in cervical samples of HIV-seropositive and -seronegative women attending a clinic in south-eastern Brazil. Both viruses were investigated by polymerase chain reaction (PCR) and cytological exams were performed. AAV was typed by PCR and restriction fragment length polymorphism analysis. AAV prevalence was 19.7% (56/284), with 18.7% (21/112) and 20.3% (35/172) in HIV-positive and -negative women, respectively. AAV type 2 was the single virus type detected. AAV was detected with higher frequency in HPV-infected women (P < 0.05) as was HPV in HIV-positive women (P < 0.05). The AAV-HPV co-infected women showed a lower rate of atypical squamous cells of undetermined significance or cervical intraepithelial neoplasia development compared with those infected only with HPV. The prevalence of AAV2 confirms this type as the most common in human samples. This is the first report examining AAV in cervical samples of HIV-infected women and indicates that HIV infection does not appear to influence AAV prevalence or AAV-HPV co-infection.

References

Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·M LagaW C Reeves
Apr 1, 1992·The Journal of General Virology·Z GrossmanB Ramot
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·N R BlacklowW P Rowe
Nov 14, 1997·The New England Journal of Medicine·X W SunT C Wright
May 20, 1998·International Journal of Cancer. Journal International Du Cancer·G La RucheG Orth
Jun 17, 1998·Journal of Virological Methods·E TobiaschJ R Schlehofer
Aug 10, 1999·Journal of Medical Virology·H D StricklerK V Shah
Sep 29, 1999·Journal of Medical Virology·K ErlesJ R Schlehofer
Mar 4, 2000·JAMA : the Journal of the American Medical Association·T V EllerbrockT C Wright
Mar 27, 2001·Experimental and Molecular Pathology·A L CokerP L Hermonat
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·J SmithJ R Schlehofer
Jul 19, 2003·São Paulo Medical Journal = Revista Paulista De Medicina·Ledy do Horto dos Santos OliveiraSilvia Maria Baeta Cavalcanti
May 28, 2004·Journal of Virology·Guangping GaoJames M Wilson
May 4, 2005·Memórias do Instituto Oswaldo Cruz·Alcina Frederica NicolMaria da Gloria Bonecini-Almeida
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J Hyun-SunA Woong-Shick
Nov 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroaki Mizukami, Keiya Ozawa
Jun 20, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Theodoros AgorastosJohn N Bontis

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Citations

Mar 5, 2016·Human Gene Therapy·Jean-Charles NaultJessica Zucman-Rossi
Nov 26, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hildegard Büning, Manfred Schmidt
Nov 9, 2016·Virus Research·J T Guidry, R S Scott
Oct 7, 2021·Expert Review of Anti-infective Therapy·Brenda Evelin Barreto da SilvaVictor Santana Santos

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Methods Mentioned

BETA
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scrapings

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