PMID: 14720146Jan 15, 2004Paper

Adenocarcinoma arising from mature cystic teratoma of the ovary

Pathology International
Miki Kushima

Abstract

An extremely rare adenocarcinoma arising from a mature cystic teratoma is reported. A 58-year-old woman underwent bilateral salpingo-oophorectomy because of a tumor in each ovary. The right ovarian tumor (solid, 9.6 x 9.6 x 6.3 cm) was a benign thecoma. Histology revealed the left ovarian cystic tumor (multilocular, 6.4 x 4.8 x 2.8 cm) was a mature cystic teratoma containing skin, fatty tissue and respiratory epithelial tissue. In addition, there was a small focal adenocarcinomatous lesion contiguous to the teratomatous ciliated columnar epithelium without stromal invasion (so-called adenocarcinoma in situ) that was suggestive of respiratory epithelium origin. However, goblet cells were present in the glandular structures of the lesion and immunohistochemical staining was segmentally strongly positive for CK20 and uniformly negative for CK7. These results suggested that the adenocarcinomatous lesion had a mucin secretory gastrointestinal phenotype. Further investigation and the collection of more cases is necessary to determine the origin and growth mechanism of adenocarcinoma arising from mature cystic teratoma of the ovary.

References

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Citations

Dec 23, 2008·Archives of Gynecology and Obstetrics·Volkan UlkerYavuz Salihoglu
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Collin J R StewartTetsuya Tsukamoto
Dec 4, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·I LataifehS Barahmeh
Mar 18, 2005·The Journal of Obstetrics and Gynaecology Research·Eun-Seop SongMoon-Whan Im
Nov 15, 2011·Diagnostic Cytopathology·David W Mensi
May 23, 2006·Pathology, Research and Practice·Kyung-Joon MinYong-Beom Kim
Jul 27, 2007·International Journal of Surgical Pathology·Norihiko SaitoHiroko Nonaka
May 28, 2009·Journal of Gynecologic Oncology·Ju Myung LeeKyu Wan Lee
Apr 24, 2012·Journal of Gynecologic Oncology·Hiroshi TakagiAtsushi Imai
Mar 5, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mary E Clark, Micah D Will
Sep 10, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lindsay WheelerAmer Karam
Sep 1, 2018·Journal of Ovarian Research·Kazuya MaedaMasahide Ohmichi
Apr 11, 2020·Clinical Case Reports·Imtinene BelaidSlim Ben Ahmed

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