Adenocarcinoma histology is a poor prognostic factor in locally advanced cervical cancer

Current Medical Research and Opinion
J Jonska-GmyrekBeata Kotowicz

Abstract

This retrospective study aimed to compare prognostic factors and survival between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in locally advanced cervical cancer treated at a single center. All medical records of cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB or IIIA,B, treated between 2004 and 2012, were reviewed. We treated patients with chemoradiotherapy (CRT) followed by brachytherapy (BT). Multivariate logistic regression and Cox proportional hazard models were used to analyze clinicopathological characteristics, patterns of care and outcomes. We included in the analysis 161 patients (52 AC; 109 SCC). Patients with AC were younger (age 50 vs. 55 years), more likely to die from the disease (HR: 1.60; 95% CI: 1.26-2.58; p = .001) and to have disease recurrence (HR: 1.69; 95% C.I: 1.21-2.12; p = .004) than those with SCC. The other significant prognostic factors for overall survival (OS) and recurrence-free survival (RFS) in AC were FIGO stage (p = .001; p = .002), WHO status (0 vs. 1-3; p = .003; p = .04), and hemoglobin level (<12 g/dl>; p = .04; p = .02). The 5 year overall survival for stage II of AC and SCC was 63% and 82% (p = .03), and for IIIA,B it was 33...Continue Reading

References

Nov 1, 1989·Gynecologic Oncology·W KleineA Pfleiderer
Sep 1, 1988·Gynecologic Oncology·L C KilgoreE E Partridge
Mar 30, 1999·Gynecologic Oncology·H IshikawaK Kuzuya
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A-C. Waldenström, G. Horvath
Apr 4, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S LiuY Mao
Jan 31, 2004·Gynecologic Oncology·A BaalbergenTh J M Helmerhorst
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Krystyna Serkies, Jacek Jassem
Dec 8, 2004·Gynecologic Oncology·Stephen A ContagEric S Calhoun
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkWui-Jin Koh
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angélica Nogueira-RodriguesCarlos G Ferreira
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration
Apr 28, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nobuhiro TakeshimaKen Takizawa
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Jun 15, 2010·International Journal of Radiation Oncology, Biology, Physics·Yi-Ting HuangJi-Hong Hong
Jan 24, 2012·Gynecologic Oncology·Vijaya GalicJason D Wright
Feb 7, 2012·Gynecologic Oncology·Jie TangSi Huang
Oct 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ericka WiebeGillian Thomas
Nov 22, 2012·Gynecologic Oncology·Maria Lina TorneselloFranco M Buonaguro
May 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Agnieszka Zolciak-SiwinskaKrzysztof Bujko
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Suthida IntaraphetPrapaporn Suprasert
Dec 18, 2013·International Journal of Radiation Oncology, Biology, Physics·Tracey SchefterUNKNOWN Radiation Therapy Oncology Group (RTOG)
Jun 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eun Jung JungDae Hoon Jeong

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