Adenocarcinoma of duodenum and ampulla of Vater: clinicopathology study and expression of p53, c-neu, TGF-alpha, CEA, and EMA

Journal of Surgical Oncology
L ZhuJ M Howard

Abstract

Oncogenes, tumor suppressor genes, and growth factors are being explored as to their role in the initiation and progression of most neoplasms, but little information exists on the expression of oncoproteins or growth factors in adenocarcinoma of the duodenum or ampulla of Vater. This report covers expressions of p53, c-neu, TGF-alpha, CEA, and EMA in duodenal adenocarcinoma and ampullary adenocarcinoma, as well as correlations between expressions and tumor stage, histological grade and patient survival. The expression of p53, c-neu, TGF-alpha, CEA, and EMA has been studied in 15 duodenal adenocarcinomas and in eight ampullary adenocarcinomas by avidin-biotin-peroxidase complex indirect immunoperoxidase technique. The positive reaction for p53, c-neu, TGF-alpha, CEA, and EMA in duodenal adenocarcinoma was 20%, 60%, 60%, 73%, and 100%, respectively, and in ampullary adenocarcinoma, 13%, 100%, 50%, 63%, and 100%. Among the duodenal tumors, C-neu and p53 expression was noted more frequently in groups with high histological grades. Patients with c-neu positive duodenal adenocarcinoma had a shorter survival than the patients with c-neu negative duodenal adenocarcinoma (P < 0.01). C-neu product may serve as an unfavorable prognostic i...Continue Reading

References

Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·M RotterH Höfler
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M KohlerE Wagner
Jan 11, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·T M WilliamsH C Maguire
Sep 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K ChangM C Willingham
Mar 15, 1990·International Journal of Cancer. Journal International Du Cancer·Y RemvikosG Thomas
Jul 1, 1990·The Journal of Pathology·P A HallN R Lemoine
Dec 15, 1989·International Journal of Cancer. Journal International Du Cancer·C R De PotterH Roels
Dec 1, 1989·American Journal of Surgery·R DelcoreA S Hermreck
Aug 1, 1989·Annals of Surgery·P J Dawson, M M Connolly
Mar 1, 1989·The Journal of Pathology·F M van den BergJ M Walboomers
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·W J GullickM D Waterfield
Apr 1, 1987·Journal of Surgical Oncology·D P Sarma, T G Weilbaecher
Aug 1, 1984·The Journal of Clinical Investigation·F J Hendler, B W Ozanne
Oct 9, 1980·The New England Journal of Medicine·M B Sporn, G J Todaro
Oct 1, 1993·Human Pathology·Y YamanakaM Korc
Feb 1, 1994·American Journal of Clinical Pathology·B J KernsL J Layfield

❮ Previous
Next ❯

Citations

Nov 23, 2010·American Journal of Clinical Pathology·Owen T M ChanHanlin L Wang
Jun 30, 2004·The American Journal of Surgical Pathology·Hui ZhouHans-Peter Fischer
Jul 14, 2001·ANZ Journal of Surgery·R R HutchinsS J Snooks
Mar 4, 2005·The American Journal of Gastroenterology·Thierry DelaunoitCharles Erlichman
Aug 13, 1999·The American Journal of Gastroenterology·B ZhaoM Makuuchi
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M TakashimaM Tsuneyoshi
Nov 8, 2013·British Journal of Cancer·T AparicioP Laurent-Puig
Jan 25, 2014·Histopathology·Iraklis PerysinakisGregory Kouraklis
Mar 30, 2017·Journal of Medical Case Reports·W S L De SilvaB K Dassanayake
Feb 2, 2006·British Journal of Hospital Medicine·D R C Spalding
May 25, 2013·Virchows Archiv : an International Journal of Pathology·Mi Jin GuUNKNOWN Korean Small Intestinal Cancer Study Group
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P GazzanigaA M Agliano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
I DiamantisA Zimmermann
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
G H SakorafasB C Golematis
© 2021 Meta ULC. All rights reserved