Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature

The American Journal of Dermatopathology
Jared J Abbott, Iftikhar Ahmed

Abstract

Mammary-like glands are a poorly recognized structure of normal vulvar skin. Adenocarcinomas arising from these glands are rare and represent a distinct clinicopathologic entity that must be distinguished from metastatic tumors. We reviewed 19 cases reported in the literature and describe a 51-year-old patient with a long-standing nodule on her right interlabial sulcus. Excisional biopsy and Mohs micrographic surgery demonstrated an infiltrating adenocarcinoma of the mammary-like glands involving the dermis and subcutis. On review of all 20 cases, the mean age at diagnosis was 59.6 years, the labia majora were involved in 13 cases (65%), and the mean lesional size was 2.5 cm. The tumor's histologic patterns varied greatly, although the histomorphologic similarity among this neoplasm, sweat gland carcinomas, and invasive extramammary Paget disease suggested a morphologic spectrum among these tumors. Criteria for establishing the diagnosis of adenocarcinoma of mammary-like glands include identifying transition zones between normal mammary-like glands and adenocarcinomatous areas. This tumor is best categorized as a locally aggressive neoplasm with a low risk for widespread metastasis. Use of aggressive surgical therapeutic regime...Continue Reading

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Citations

Mar 23, 2013·The American Journal of Dermatopathology·Giorgio BoganiFabio Ghezzi
Mar 29, 2008·Journal of Lower Genital Tract Disease·Andrea GrinDanny Ghazarian
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Dmitry V KazakovMichal Michal
Aug 3, 2006·Journal of Clinical Pathology·Nidal A ObaidatDanny Ghazarian
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Dec 21, 2010·Advances in Anatomic Pathology·Dmitry V KazakovMichal Michal
May 11, 2019·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Stephanie LarsonElaine Hart
Apr 8, 2020·The Breast Journal·Ameya A DeshmukhJennifer A Crozier
Mar 10, 2016·The American Journal of Dermatopathology·James Robert DuncanAlejandro Gru
Jul 7, 2012·The Journal of Obstetrics and Gynaecology Research·Virginia BenitoOctavio Arencibia
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Oct 10, 2020·Seminars in Diagnostic Pathology·Mohamed Mokhtar Desouki, Oluwole Fadare
Oct 10, 2008·Pathology, Research and Practice·Khaled O AlsaadDanny Ghazarian

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