Adenocarcinoma of the lung with concomitant ALK fusion gene and EGFR gene mutation: A case report and literature review

Molecular and Clinical Oncology
Tao FanXiu-Li Liu

Abstract

Targeted therapy is currently a very popular approach to cancer treatment. Personalized targeted therapy of non-small-cell lung cancer (NSCLC) is based on the mutation status of epithelial growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog, B-Raf proto-oncogene and anaplastic lymphoma kinase (ALK) fusion gene, with different mutations requiring different treatment. Herein, we present a rare case of adenocarcinoma of the lung harboring EGFR- and ALK-activating mutations simultaneously. The patient is currently on pemetrexed and carboplatin chemotherapy and faring well; follow-up will be continued. It is recommended that the biological behavior of cancers with coexisting genetic mutations and their clinicopathological characteristics are more closely investigated in future studies, in order to determine the sensitivity of such cancers to targeted drugs and select the optimal agent.

References

Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Sep 14, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jenn-Yu WuPan-Chyr Yang
May 25, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·June Koo LeeYung-Jue Bang
Jun 5, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiaoxia ChenCaicun Zhou

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