Adenocarcinoma of the Rectum-A Composite of Three Different Subtypes With Varying Outcomes?

Clinical Colorectal Cancer
Karthik Chandra VallamAvanish P Saklani

Abstract

Adenocarcinoma of the rectum has been classified by the World Health Organization into various histologic subtypes. We analyzed the effect of the histologic subtype (classic, signet ring cell, and mucinous) on the clinical outcomes of patients with rectal cancer. We hypothesized that clinicopathologic outcome measures such as tumor margins, tumor regression grade, recurrence rate, and survival would vary with the histologic subtype. We conducted a retrospective analysis of a prospectively maintained database. All patients with stage I-III rectal adenocarcinoma were included. From May 2010 to August 2013, 273 patients underwent curative resection. Both mucin-secreting variants were more common in younger patients and presented at a more advanced stage. Also, 54% and 48% of those with signet ring cell carcinoma (SRCC) and mucinous adenocarcinoma (MAC) had node-positive disease compared with the rate in the classic variant (30%). Circumferential resection margin positivity was 24% with MAC and 19% with SRCC compared with 4% with the classic variant. Disease-free survival for those with the classic and mucinous variants was 38.5 and 37.4 months, respectively. In contrast, it was 28.6 months in the SRCC group. The overall survival d...Continue Reading

Citations

Jan 23, 2018·Annals of Coloproctology·Sang-Oh YunJung Wook Huh
Aug 11, 2020·International Journal of Colorectal Disease·Heita OzawaKenichi Sugihara
Sep 9, 2016·South Asian Journal of Cancer·Nikhil Suresh GhadyalpatilSaklani Avanish
Jun 23, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Mufaddal KaziAvanish Saklani
Aug 6, 2021·Journal of Surgical Oncology·Mufaddal KaziAvanish Saklani
Jun 20, 2021·International Journal of Cancer. Journal International Du Cancer·Nazia ChaudharySorab N Dalal

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