PMID: 7842287May 1, 1994Paper

Adenocarcinoma of the small intestine: 21-year review of diagnosis, treatment, and prognosis

Annals of Surgical Oncology
R L BauerH O Douglass

Abstract

The purpose of this study was to evaluate the tumor characteristics and treatment associated with an improved overall survival in patients with adenocarcinoma of the small intestine. The records of all patients with primary adenocarcinoma of the small bowel seen between January 1971 and December 1991 were reviewed retrospectively. The study comprised 38 patients, 22 (58%) with duodenal tumors, 11 (29%) with jejunal tumors, and five (13%) with ileal tumors. Although not statistically significant, the patients with duodenal adenocarcinoma lived longer than the patients with jejunal or ileal lesions (p = 0.77). The overall survival was 23% and seemed to correlate best with absence of lymph node metastases (p = 0.04) and pancreaticoduodenectomy for localized duodenal tumors (p = 0.04). The patient's age, duration of symptoms, disease-free interval, tumor location, type of recurrence, and histologic grade did not significantly influence survival. The lethality of small-intestinal adenocarcinoma appears to be related to a delay in diagnosis and treatment. When a definitive surgical procedure is performed before lymph node metastases appear, the patient's chance for long-term survival is greatly improved.

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Citations

Jul 26, 2006·The American Journal of Gastroenterology·Dharmendra Verma, John R Stroehlein
Jul 13, 2018·Virchows Archiv : an International Journal of Pathology·Aoife Maguire, Kieran Sheahan
Jul 14, 2001·ANZ Journal of Surgery·R R HutchinsS J Snooks
Jun 6, 2007·Annals of Surgical Oncology·Shefali AgrawalAshwani Rajput
Jul 9, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sylvain ManfrediBernard Meunier
Apr 20, 2010·Acta Oncologica·Michael J OvermanRobert A Wolff
Sep 18, 2009·Journal of Cancer Research and Clinical Oncology·Yong Wha MoonJae Kyung Roh
Nov 11, 2008·Japanese Journal of Clinical Oncology·Sook Hee HongSuk Kyun Chang
Aug 29, 2018·JAAPA : Official Journal of the American Academy of Physician Assistants·Ashley Hafer
May 7, 2005·International Journal of Clinical Practice. Supplement·R Varghese, R Weedon
Feb 16, 2006·World Journal of Surgery·Ting-Jung WuMiin-Fu Chen
Jan 16, 2014·The Indian Journal of Surgery·Priti Prasad Shah, Sudhir Kothari
Jul 20, 2007·The Cochrane Database of Systematic Reviews·N Singhal, D Singhal
May 19, 2011·The British Journal of Radiology·M AnzideiR Passariello
Oct 7, 2004·Cancer Research·D Dean PotterStephen N Thibodeau

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