Adenocarcinoma of the uterine cervix: Pathologic features, treatment options, clinical outcome and prognostic variables

Critical Reviews in Oncology/hematology
Angiolo GadducciStefania Cosio

Abstract

Adenocarcinoma accounts for 10-25% of all cervical cancers, and its relative and absolute rate has raised over the past decades. Most, but not all the authors, reported that adenocarcinoma has a greater propensity to lymph node, ovarian and distant metastases and a worse prognosis compared with squamous cell carcinoma. However, whether histologic type is an independent prognostic factor is still a debated issue. Moreover, adenocarcinoma is a very heterogenous disease, including different histological subtypes. Whereas radical hysterectomy and definitive radiotherapy achieve the same clinical outcome in early stage squamous cell carcinoma, surgery seems to obtain better survival compared with definitive radiotherapy in early stage adenocarcinoma. Chemoradiation is the standard treatment for locally advanced cervical cancer regardless of histologic type, although several retrospective studies showed that patients with adenocarcinoma were more likely to die than those with squamous cell carcinoma both before and after concurrent chemoradiation era. The prognostic relevance of biological variables, such as cyclin-dependent kinase inhibitors, p53, cyclooxygenase-2 [COX-2], cell surface tyrosine-kinases and programmed death-ligand [P...Continue Reading

Citations

Aug 20, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lijie CaoXiaohua Wu
Jun 12, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Noriaki SakuragiHidemichi Watari
Jan 12, 2021·Frontiers in Immunology·Jossie RotmanEkaterina S Jordanova
Feb 23, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tingting LeiJia He
Dec 3, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Máire A DugganAylin Sar
Apr 14, 2021·Science Progress·Meilian DongRuitai Fan
Jul 31, 2021·OncoTargets and Therapy·Qianqian ZhangYouzhong Zhang

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