Adenocarcinoma Prostate With Neuroendocrine Differentiation: Potential Utility of 18F-FDG PET/CT and 68Ga-DOTANOC PET/CT Over 68Ga-PSMA PET/CT.

Clinical Nuclear Medicine
Girish Kumar ParidaShamim Ahmed Shamim

Abstract

Ga-PSMA PET/CT is the upcoming imaging modality for staging, restaging and response assessment of prostate cancer. However, due to neuroendocrine differentiation in some of patients with prostate cancer, they express somatostatin receptors instead of prostate specific membrane antigen. This can be exploited and other modalities like Ga-DOTANOC PET/CT and F-FDG PET/CT should be used in such cases for guiding management. We hereby discuss a similar case of 67-year-old man of adenocarcinoma prostate with neuroendocrine differentiation, which shows the potential pitfall of Ga-PSMA PET/CT imaging and benefit of Ga-DOTANOC PET/CT and F-FDG PET/CT in such cases.

References

Jun 21, 2008·World Journal of Surgical Oncology·Yiyan Liu
Apr 12, 2014·Frontiers in Oncology·Stéphane Terry, Himisha Beltran
Mar 19, 2015·Frontiers in Oncology·Alexandru Dan GrigoreMary C Farach-Carson
Feb 28, 2017·Clinical Nuclear Medicine·Sharjeel UsmaniFareeda Al Kandari

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Citations

Jan 15, 2020·Prostate Cancer and Prostatic Diseases·Salma MeziouFrédéric Pouliot
Oct 17, 2018·Clinical Nuclear Medicine·Emine Acar, Gamze Çapa Kaya
Jul 24, 2020·Current Opinion in Urology·Aravind S Ravi KumarMichael S Hofman
Nov 8, 2018·Endocrine-related Cancer·Martin K BakhtLisa A Porter
Jan 10, 2019·Clinical Nuclear Medicine·Jiaqiong Wang
Jun 6, 2019·AJR. American Journal of Roentgenology·Saabry OsmanyHossein Jadvar
Feb 3, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Ruohua ChenJianjun Liu
Jul 13, 2021·Future Oncology·Phillip J Koo, Daniel Petrylak

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