Adenoid cystic carcinoma of the head and neck--a 20 years experience

International Journal of Oral and Maxillofacial Surgery
H KokemuellerJ-E Hausamen

Abstract

In this retrospective study we give a clinical review of our experience with adenoid cystic carcinoma (ACC) and compare our results with those reported in the literature. Between 1981 and 2000, 74 patients with this disease were treated at our department. Complete resection was reached in 45 cases. Fourteen patients received postoperative radiation. Local control rates at 5, 10 and 15 years were 64%, 56% and 52% with a mean local control time of 11.1 years. Tumour size (P<or= 0.001), perineural invasion (P<or= 0.001) and margin status (P<or= 0.001) showed significant influence on local control. Statistically, we were not able to demonstrate a positive effect for postoperative radiation. Distant control rates at 5, 10 and 15 years were 72%, 62% and 59% with a mean distant control time of 14.4 years. Distant failure was diagnosed in lungs and bones and occurred independently of local treatment outcome. Overall survival rates at 5, 10 and 15 years were 71%, 54% and 37% with a mean overall survival of 11.2 years. Recurrence-free survival rates at 5, 10 and 15 years were 57%, 45% and 37% with a mean recurrence-free survival of 9.1 years. The survival rates at 5, 10 and 15 years after diagnosis of tumour progression were 35%, 15% and...Continue Reading

Citations

Aug 25, 2012·Contemporary Clinical Dentistry·Pournima GodgeMonica Yadav
Jan 1, 2012·ISRN Otolaryngology·Victor Shing Howe ToWilliam I Wei
Dec 1, 2013·Journal of Adolescent and Young Adult Oncology·Alicia Nassar, Kelly K Sawczyn
Apr 26, 2013·The Oncologist·Krzysztof J MisiukiewiczMarshall Posner
Dec 2, 2015·Oncology Letters·Guanqiao LiShiping Yang
Jan 29, 2016·Case Reports in Otolaryngology·Kurren S Gill, Mark A Frattali
Nov 5, 2005·Oral Diseases·E C OtohO A Adeleke
Aug 23, 2005·International Journal of Oral and Maxillofacial Surgery·A J Lyons, J Jones X-T Xie
Dec 16, 2004·Oral Oncology·Horst KokemuellerAndré Eckardt
Aug 31, 2014·Virchows Archiv : an International Journal of Pathology·Roderick H W SimpsonIlmo Leivo
Feb 23, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Nannan HanChenping Zhang
Dec 25, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Emily MarchianoJean Anderson Eloy
Mar 29, 2011·Journal of Dental Research·L DongC Y Wang
Aug 3, 2018·Virchows Archiv : an International Journal of Pathology·Simon AndreasenPreben Homøe
Oct 1, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xiaojing LiuFenghe Zhang
Apr 14, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Huipeng MaJianhua Qin
Nov 2, 2018·Journal of Cancer Research and Clinical Oncology·Beata JagielskaJanusz A Siedlecki
Jun 22, 2007·Clinical Nuclear Medicine·Nikhil BhagatNasrin V Ghesani
Mar 19, 2008·Journal of Cancer Research and Clinical Oncology·Adam D Elkin, Charlotte D Jacobs
Jul 4, 2007·Pathology Oncology Research : POR·Danyel Elias da Cruz PerezLuiz Paulo Kowalski
Jun 15, 2007·Nihon Jibiinkoka Gakkai kaiho·Mari AdachiToshio Yamashita
Aug 27, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yaling TangYu Chen
Apr 30, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M-W HuangJ-G Zhang
Nov 23, 2013·Interventional Medicine & Applied Science·Sherif El-NagdyMohamed I Mourad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.