Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Simon AndreasenPreben Homøe

Abstract

Adenoid cystic carcinoma is among the most frequent malignancies in the salivary and lacrimal glands and has a grave prognosis characterized by frequent local recurrences, distant metastases, and tumor-related mortality. Conversely, adenoid cystic carcinoma of the breast is a rare type of triple-negative (estrogen and progesterone receptor, HER2) and basal-like carcinoma, which in contrast to other triple-negative and basal-like breast carcinomas has a very favorable prognosis. Irrespective of site, adenoid cystic carcinoma is characterized by gene fusions involving MYB, MYBL1, and NFIB, and the reason for the different clinical outcomes is unknown. In order to identify the molecular mechanisms underlying the discrepancy in clinical outcome, we characterized the phenotypic profiles, pattern of gene rearrangements, and global microRNA expression profiles of 64 salivary gland, 9 lacrimal gland, and 11 breast adenoid cystic carcinomas. All breast and lacrimal gland adenoid cystic carcinomas had triple-negative and basal-like phenotypes, while salivary gland tumors were indeterminate in 13% of cases. Aberrations in MYB and/or NFIB were found in the majority of cases in all three locations, whereas MYBL1 involvement was restricted t...Continue Reading

References

Dec 1, 1987·Human Pathology·J Y RoH S Gallager
Dec 10, 1998·Nucleic Acids Research·H OgataM Kanehisa
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Jul 2, 2003·Journal of Clinical Pathology·M Pia-FoschiniS R Lakhani
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 9, 2007·Breast Cancer Research and Treatment·David S P TanJorge S Reis-Filho
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
Sep 19, 2009·Nature Reviews. Genetics·Carlo M Croce
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marta PerssonGöran Stenman
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K David VoducHagen Kennecke
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sunil BadveJorge S Reis-Filho
Mar 8, 2011·Trends in Molecular Medicine·Cathy A AndorferEdith A Perez
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Louis B BrillHenry F Frierson
May 18, 2011·Journal of Proteome Research·Helen M MooreJim Vaught
Apr 12, 2012·Carcinogenesis·Marilena V Iorio, Carlo M Croce
May 25, 2012·Cell and Tissue Research·Mahboob Ul Hussain
May 21, 2013·Nature Genetics·Allen S HoTimothy A Chan
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Jun 20, 2013·The Journal of Clinical Investigation·Philip J StephensP Andrew Futreal
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Oct 29, 2013·Breast Cancer Research and Treatment·Hugo M HorlingsJorge S Reis-Filho
Mar 1, 2014·Archives of Pathology & Laboratory Medicine·Jena B Hudson, Brian T Collins
Nov 12, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael T AndreoliPete Setabutr
Nov 19, 2014·Journal of Dental Research·R E MellasO J Baker
Nov 25, 2014·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Dec 18, 2014·World Journal of Clinical Cases·Kosuke MiyaiJae Y Ro
May 16, 2015·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Jun 11, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Simon AndreasenPreben Homøe
Jun 23, 2015·The Journal of Pathology·Luciano G MartelottoBritta Weigelt
Aug 8, 2015·Oncotarget·Shumei KatoRazelle Kurzrock

❮ Previous
Next ❯

Citations

Apr 6, 2018·Virchows Archiv : an International Journal of Pathology·Petr ŠteinerAlena Skálová
Nov 15, 2018·The Journal of Pathology·Amy E McCart ReedSunil R Lakhani
Feb 28, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Simon AndreasenIrene Wessel
Dec 7, 2018·The American Journal of Surgical Pathology·Simon AndreasenRobert B West
Sep 10, 2020·International Journal of Molecular Sciences·Stefano MartellucciSilvia Zappavigna
Oct 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fresia ParejaJorge S Reis-Filho
May 27, 2021·Case Reports in Pathology·Lin HePayal Kapur
Jul 13, 2021·Frontiers in Oncology·Kristian EgebjergMorten Mau-Sørensen
Oct 3, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher J SchwartzHannah Y Wen
Oct 14, 2019·Oral Oncology·Yue JiangFrederic J Kaye

❮ Previous
Next ❯

Software Mentioned

R package preprocessCore
R
SPSS
miRPath
DIANA

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

The New England Journal of Medicine
William D FoulkesJorge S Reis-Filho
Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
C M Eneroth
The Journal of Laryngology and Otology
M E Johns, J G Batsakis
© 2022 Meta ULC. All rights reserved