PMID: 9530889Apr 8, 1998Paper

Adenoma with clear cell change of the large intestine

Journal of Surgical Oncology
H SuzukiK Nagashima

Abstract

Clear cell change of the large intestinal neoplasm is rare, and its character remains unclear. We report a case of the large intestinal adenoma with clear cell change with immunohistochemical and molecular studies to investigate whether the clear cell change is associated with a malignant progression of the adenoma. We studied the histochemical and immunohistochemical staining characteristics of the tumor by staining with hematoxylin-eosin, periodic acid-Schiff, alcian blue, and by immunostaining using antibodies against carcinoembryonic antigen, epithelial membrane antigen, p53, and Ki-67. The c-K-ras codon 12 point mutations were analyzed using a nonradioactive restriction fragment length polymorphism technique. The tumor was composed of a typical tubular adenoma and a tubular adenoma with clear cytoplasm. The clear cytoplasm was negative by mucin stains. Immunohistochemically p53 was negative in both the components. Labeling index of Ki-67 showed no significant difference between the two components. No codon 12 mutation of c-K-ras gene was observed in both the components. These findings suggest that the clear cell change of the tubular adenoma is not associated with a malignant progression in adenoma-carcinoma sequence invol...Continue Reading

Citations

Apr 10, 2014·Case Reports in Oncological Medicine·Christian Daniel Barrera-MaldonadoSue Sim
Feb 21, 2008·World Journal of Gastroenterology : WJG·Koichi SogaTakanori Hattori
May 12, 2019·Diagnostic Pathology·Yuzo OyamaTsutomu Daa
Jan 23, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·H Suzuki, Y Fujioka
Jul 10, 2008·International Journal of Surgical Pathology·Catarina EloyFátima Carneiro
Aug 1, 2018·Clinical Journal of Gastroenterology·Tomomasa TochioGen Watanabe
Sep 28, 2020·Histopathology·Parag D DabirIris D Nagtegaal
Jan 10, 2021·Clinical Journal of Gastroenterology·Tomomasa TochioRyoji Kushima

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