Adenomas - Genetic factors in colorectal cancer prevention

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Kycler WitoldJanowski Jakub

Abstract

Colorectal cancer is the second most common type of cancer both in Europe and Poland. During the last 30 years more than a 3-fold increase has been observed in Poland due to environmental and genetic factors. Almost all colorectal malignancies are related to the formation and malignant transformation of colorectal dysplasia and adenoma. Efforts aiming to decrease the number of colorectal cancer deaths are focused on the disease early detection. Genetic diagnosis for hereditary syndromes predisposing to colorectal cancer has been developed and is a part of the routine treatment. Most cancers are sporadic. They often develop from polyps in the colon. In addition to the genetic events described in the 1990s, showing the adenoma transformation into carcinoma that has been a prime example of malignant transformation for a long time, there are also other possibilities of neoplastic transformation. The recognition of colorectal cancer risk factors make sense as their nature is lifestyle- and diet-related. In this review paper those risk factors are presented and the prevention of colorectal cancer is discussed taking into account genetic factors.

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Citations

Jan 16, 2020·International Journal of Molecular Sciences·Teodora CosteaMaria-Magdalena Mocanu
Aug 31, 2019·PloS One·Lukasz GmerekMichal M Masternak
Jun 14, 2020·International Journal of Molecular Sciences·Enzo SpisniMaria Chiara Valerii
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Nov 30, 2018·International Journal of Molecular Sciences·Teodora CosteaMaria-Magdalena Mocanu
Jul 3, 2021·European Journal of Gastroenterology & Hepatology·Lili LiuHao Wu

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