Adenopharyngoplasty vs Adenotonsillectomy in Children With Severe Obstructive Sleep Apnea: A Randomized Clinical Trial

JAMA Otolaryngology-- Head & Neck Surgery
Johan FehrmDanielle Friberg

Abstract

Adenotonsillectomy (ATE) is the primary surgical method for treating obstructive sleep apnea (OSA) in children. However, children with severe OSA have an increased risk for residual OSA after ATE. Previous studies indicate that adenopharyngoplasty (APP), a modified ATE with closure of the tonsillar pillars, might improve the surgical outcome, but the overall evidence is weak. To determine whether APP is more effective than ATE for treating severe OSA in otherwise healthy children. A blinded randomized clinical trial was conducted at the otorhinolaryngology department at Karolinska University Hospital, Stockholm, Sweden. Eighty-three children, aged 2 to 4 years, with an obstructive apnea-hypopnea index (OAHI) score of 10 or higher, were randomized to APP (n = 36) or ATE (n = 47). Participants were recruited from December 1, 2014, through November 31, 2016. Adenotonsillectomy was performed in all 83 patients in both groups by the cold steel technique. The APP group also underwent closure of the tonsillar pillars with 2 inverted sutures on each side. The primary outcome was the difference between the groups in OAHI score change before and after surgery. A higher score indicates worse problems and a score of 10 or higher is defined...Continue Reading

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References

Dec 1, 1989·Pediatric Clinics of North America·L Brodsky
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·J B SchellenbergR J Schwab
Jan 8, 2004·The Laryngoscope·Christian GuilleminaultSandra Martinez
Oct 19, 2004·International Journal of Pediatric Otorhinolaryngology·Ron B Mitchell, James Kelly
Dec 2, 2006·The Journal of Pediatrics·Riva TaumanDavid Gozal
Feb 6, 2008·Proceedings of the American Thoracic Society·Oscar Sans CapdevilaDavid Gozal
Mar 4, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cristina M BaldassariEmily F Rudnick
Mar 31, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Dary J Costa, Ron Mitchell
May 27, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael FriedmanHsueh-Wen Chang
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Rakesh BhattacharjeeDavid Gozal
Sep 24, 2010·The Annals of Otology, Rhinology, and Laryngology·Jin YeYuan Li
Mar 14, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael FriedmanT K Venkatesan
Aug 29, 2012·Pediatrics·Carole L MarcusUNKNOWN American Academy of Pediatrics
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
May 23, 2013·The New England Journal of Medicine·Carole L MarcusUNKNOWN Childhood Adenotonsillectomy Trial (CHAT)
Sep 24, 2013·International Journal of Pediatric Otorhinolaryngology·Anna BorgströmDanielle Friberg
Oct 25, 2016·The Laryngoscope·Matin Imanguli, Seckin O Ulualp
Jul 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cameron A ToddKimsey H Rodriguez

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Citations

May 18, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Johan FehrmDanielle Friberg
Aug 25, 2020·International Journal of Pediatric Otorhinolaryngology·Paula Martínez-Ruiz de ApodacaEduard Esteller-Moré

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