Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro

Endocrinology
M J OdomCarole R Mendelson

Abstract

The use of beta-adrenergic agonists in the treatment of preterm labor has been found to be associated with a decreased incidence of respiratory distress syndrome (RDS) in premature newborns. beta-Sympathomimetic agents, which activate adenylate cyclase and increase tissue cAMP levels, as well as cAMP analogs stimulate surfactant glycerophospholipid synthesis and secretion by fetal lung tissue. In the present study, we used antibodies directed against the major human pulmonary surfactant apoprotein, a 35,000-dalton glycoprotein, to evaluate the effects of the cAMP analog dibutyryl cAMP (Bt2cAMP) and the beta-adrenergic agonist terbutaline on surfactant apoprotein synthesis in human fetal lung explants in organ culture. By use of immunoblot analysis, we found that Bt2cAMP (1 mM) markedly stimulated accumulation of the major surfactant apoprotein in human fetal lung explants, as did terbutaline. Bt2cAMP treatment also increased the relative rate of incorporation of [35S]methionine into the major surfactant apoprotein. The Bt2cAMP-induced increase in surfactant apoprotein synthesis and accumulation was associated with an increase in the levels of translatable surfactant apoprotein mRNA. Morphometric analysis at both the light and e...Continue Reading

Citations

Apr 25, 2000·Indian Journal of Pediatrics·A R Kumar, J M Snyder
Nov 3, 1993·Biochimica Et Biophysica Acta·A SharmaP L Ballard
May 17, 2014·Differentiation; Research in Biological Diversity·Aadil KaisaniJerry W Shay
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·C R Mendelson, V Boggaram
May 6, 2003·Reproduction, Fertility, and Development·Sandra OrgeigLucy C Sullivan
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H G LileyP L Ballard
Mar 1, 1996·The Proceedings of the Nutrition Society·R HumeM Gilmour
Sep 27, 2006·Molecular and Cellular Biology·Iwona GradDidier Picard
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dongyuan LiuCarole R Mendelson
Apr 13, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip L BallardMichael A Matthay
Dec 31, 1997·American Journal of Respiratory Cell and Molecular Biology·J L AlcornC R Mendelson
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·R R Hoover, J Floros
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·M J AcarreguiJ M Snyder
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·J A GutierrezL G Dobbs
Feb 1, 1990·American Journal of Respiratory Cell and Molecular Biology·P L BallardM C Williams
Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·B E MillerG E Hook
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Jorge A GutierrezLeland G Dobbs
Feb 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Kelly C WadePhilip L Ballard
Apr 1, 1989·The Journal of Clinical Investigation·H G LileyP L Ballard
Mar 14, 2009·Molecular Endocrinology·Carole R Mendelson
Jul 16, 2011·PloS One·Oliver DelgadoJerry W Shay
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer C CondonCarole R Mendelson
Aug 28, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Linda FonsecaAlex C Vidaeff
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·T Spillman, D B Cotton
Jun 7, 2011·Respiratory Physiology & Neurobiology·Sandra OrgeigChristopher B Daniels
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·P L Ballard
Jul 24, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emmanuel LopezCéline Méhats
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Carole R Mendelson, Jennifer C Condon
Sep 1, 1989·Trends in Endocrinology and Metabolism : TEM·C R Mendelson, V Boggaram
Jun 23, 2015·The Journal of Clinical Investigation·Lu GaoCarole R Mendelson
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Kim A GertenLinda R Chambliss
Jun 5, 2007·Immunobiology·Grith Lykke SorensenUffe Holmskov
Jun 2, 1998·Biochimica Et Biophysica Acta·M J AcarreguiS T Penisten
Nov 14, 1998·Biochimica Et Biophysica Acta·C R MendelsonJ L Alcorn
Nov 25, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph L AlcornCarole R Mendelson

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