Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro

M J OdomCarole R Mendelson


The use of beta-adrenergic agonists in the treatment of preterm labor has been found to be associated with a decreased incidence of respiratory distress syndrome (RDS) in premature newborns. beta-Sympathomimetic agents, which activate adenylate cyclase and increase tissue cAMP levels, as well as cAMP analogs stimulate surfactant glycerophospholipid synthesis and secretion by fetal lung tissue. In the present study, we used antibodies directed against the major human pulmonary surfactant apoprotein, a 35,000-dalton glycoprotein, to evaluate the effects of the cAMP analog dibutyryl cAMP (Bt2cAMP) and the beta-adrenergic agonist terbutaline on surfactant apoprotein synthesis in human fetal lung explants in organ culture. By use of immunoblot analysis, we found that Bt2cAMP (1 mM) markedly stimulated accumulation of the major surfactant apoprotein in human fetal lung explants, as did terbutaline. Bt2cAMP treatment also increased the relative rate of incorporation of [35S]methionine into the major surfactant apoprotein. The Bt2cAMP-induced increase in surfactant apoprotein synthesis and accumulation was associated with an increase in the levels of translatable surfactant apoprotein mRNA. Morphometric analysis at both the light and e...Continue Reading


Apr 25, 2000·Indian Journal of Pediatrics·A R Kumar, J M Snyder
Nov 3, 1993·Biochimica Et Biophysica Acta·A SharmaP L Ballard
May 17, 2014·Differentiation; Research in Biological Diversity·Aadil KaisaniJerry W Shay
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·C R Mendelson, V Boggaram
May 6, 2003·Reproduction, Fertility, and Development·Sandra OrgeigLucy C Sullivan
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H G LileyP L Ballard
Mar 1, 1996·The Proceedings of the Nutrition Society·R HumeM Gilmour
Sep 27, 2006·Molecular and Cellular Biology·Iwona GradDidier Picard
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dongyuan LiuCarole R Mendelson
Apr 13, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip L BallardMichael A Matthay
Dec 31, 1997·American Journal of Respiratory Cell and Molecular Biology·J L AlcornC R Mendelson
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·R R Hoover, J Floros
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·M J AcarreguiJ M Snyder
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·J A GutierrezL G Dobbs
Feb 1, 1990·American Journal of Respiratory Cell and Molecular Biology·P L BallardM C Williams
Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·B E MillerG E Hook
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Jorge A GutierrezLeland G Dobbs
Feb 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Kelly C WadePhilip L Ballard
Apr 1, 1989·The Journal of Clinical Investigation·H G LileyP L Ballard
Mar 14, 2009·Molecular Endocrinology·Carole R Mendelson
Jul 16, 2011·PloS One·Oliver DelgadoJerry W Shay
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer C CondonCarole R Mendelson
Aug 28, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Linda FonsecaAlex C Vidaeff
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·T Spillman, D B Cotton
Jun 7, 2011·Respiratory Physiology & Neurobiology·Sandra OrgeigChristopher B Daniels
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·P L Ballard
Jul 24, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emmanuel LopezCéline Méhats
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Carole R Mendelson, Jennifer C Condon
Sep 1, 1989·Trends in Endocrinology and Metabolism : TEM·C R Mendelson, V Boggaram
Jun 23, 2015·The Journal of Clinical Investigation·Lu GaoCarole R Mendelson
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Kim A GertenLinda R Chambliss
Jun 5, 2007·Immunobiology·Grith Lykke SorensenUffe Holmskov
Jun 2, 1998·Biochimica Et Biophysica Acta·M J AcarreguiS T Penisten
Nov 14, 1998·Biochimica Et Biophysica Acta·C R MendelsonJ L Alcorn
Nov 25, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph L AlcornCarole R Mendelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.