Adenosine 5-diphosphate-ribose is a neural regulator in primate and murine large intestine along with β-NAD(+).

The Journal of Physiology
Leonie DurninVioleta N Mutafova-Yambolieva

Abstract

Adenosine 5′-triphosphate (ATP) has long been considered to be the purine inhibitory neurotransmitter in gastrointestinal (GI) muscles, but recent studies indicate that another purine nucleotide, β-nicotinamide adenine dinucleotide (β-NAD(+)), meets pre- and postsynaptic criteria for a neurotransmitter better than ATP in primate and murine colons. Using a small-volume superfusion assay and HPLC with fluorescence detection and intracellular microelectrode techniques we compared β-NAD(+) and ATP metabolism and postjunctional effects of the primary extracellular metabolites of β-NAD(+) and ATP, namely ADP-ribose (ADPR) and ADP in colonic muscles from cynomolgus monkeys and wild-type (CD38(+/+)) and CD38(−/−) mice. ADPR and ADP caused membrane hyperpolarization that, like nerve-evoked inhibitory junctional potentials (IJPs), were inhibited by apamin. IJPs and hyperpolarization responses to ADPR, but not ADP, were inhibited by the P2Y1 receptor antagonist (1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt (MRS2500). Degradation of β-NAD(+) and ADPR was greater per unit mass in muscles containing only nerve processes than in muscles also...Continue Reading

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Citations

Mar 25, 2014·Pflügers Archiv : European journal of physiology·Noemí MañéMarcel Jiménez
Oct 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Leonie DurninVioleta N Mutafova-Yambolieva
Jun 5, 2013·The Journal of Physiology·Jane A RobertsGary M Mawe
Mar 5, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Diana GallegoMarcel Jiménez
Dec 17, 2015·Scientific Reports·Casey M DanielsAnthony K L Leung
Jul 16, 2013·The FEBS Journal·Michele Di Stefano, Laura Conforti
Feb 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R K GoyalA Chaudhury
Jun 10, 2015·Autonomic Neuroscience : Basic & Clinical·Charles Kennedy
Jun 8, 2015·Autonomic Neuroscience : Basic & Clinical·Brian F King
Jul 1, 2016·Scientific Reports·Ping-Ping ZhangYong-Mei Zhong
May 27, 2014·Inflammatory Bowel Diseases·Fernando Ochoa-CortesFievos L Christofi
Jul 29, 2016·American Journal of Physiology. Renal Physiology·Leonie DurninVioleta N Mutafova-Yambolieva
Oct 3, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Violeta N Mutafova-Yambolieva, Kenton M Sanders
Sep 4, 2012·IUBMB Life·Violeta N Mutafova-Yambolieva
Jul 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L E PeriV N Mutafova-Yambolieva
Jan 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L DurninV N Mutafova-Yambolieva
Jul 15, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leonie DurninVioleta N Mutafova-Yambolieva
Apr 9, 2020·Frontiers in Oncology·Valentina AudritoSilvia Deaglio
Jun 26, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sang Don KohK M Sanders
May 2, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriIrene Busciglio
Apr 10, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L DurninV N Mutafova-Yambolieva
Jun 20, 2021·Autonomic Neuroscience : Basic & Clinical·Kenton M Sanders, Violeta N Mutafova-Yambolieva
Aug 24, 2021·Frontiers in Immunology·Valentina AudritoSilvia Deaglio

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