PMID: 15250231Jul 15, 2004Paper

Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma

Respiratory Medicine
E BucchioniS A Kharitonov

Abstract

Hyperresponsiveness (AHR) is a key physiological abnormality in asthma. In clinical and research studies AHR is measured bronchial challenge, with methacholine (MCh), but more recently with adenosine-5'-monophosphate (AMP). In the search for markers of airway inflammation in asthmatic patients, we measured the concentrations of histamine and cysteinyl-leukotrienes (cys-LTs) before and after MCh and AMP challenges in the exhaled breath condensate of 13 patients with mild asthma (FEV1 78.5%pred) and nine healthy non-smokers, using specific enzyme immunoassays. With methacholine challenge we did not find any differences between asthmatics and normal subjects in the pre- and post-challenge concentrations of cys-LTs: 27.2+/-1.4 vs. 29.2+/-1.2 pg/ml and 26.3+/-2.2 vs. 27.5+/-4.2 pg/ml, respectively or histamine: 5.1+/-0.4 vs. 5.1+/-0.6 nM and 4.5+/-0.4 vs. 4.4+/-0.3 nM; P>0.05). In asthmatic patients cys-LT levels were significantly higher after AMP challenge (56.2+/-9.7 vs. 31.7+/-6.9 pg/ml; P<0.05); but there was no difference in healthy subjects (27.2+/-4.6 vs. 30.3+/-4.7 pg/ml). There was no difference in histamine concentrations in asthmatic (5.9+/-1.8 vs. 4.5+/-0.5 nM), or healthy subjects (5.5+/-0.4 vs.5.7+/-0.9 nM) after AMP ...Continue Reading

References

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Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes

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Citations

Dec 10, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma· RatnawatiPaul S Thomas
Jul 31, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jason S DebleyEdward R Carter
Jul 28, 2007·The Journal of Allergy and Clinical Immunology·Jason S DebleyJerry Zimmerman
Mar 21, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K KostikasS Loukides
May 18, 2010·Respiratory Medicine·Claudio MastruzzoNunzio Crimi
Mar 15, 2005·Respiratory Medicine·Daniel K C LeeGraeme P Currie
Feb 8, 2006·Respiration; International Review of Thoracic Diseases·Anette DavidssonBirgitta Schmekel
Mar 9, 2011·Journal of Breath Research·Shamsah Kazani, Elliot Israel
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Amir Mohsenin, Michael R Blackburn
May 22, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael R Blackburn
Jun 3, 2021·International Journal of Molecular Sciences·Bianca S Romero-MartínezEdgar Flores-Soto

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