Adenosine 5'-triphosphate and noradrenaline are excitatory cotransmitters to the fibromuscular stroma of the guinea pig prostate gland

European Journal of Pharmacology
Rosanda Buljubasich, S Ventura

Abstract

Immunohistochemical studies demonstrated abundant P2X(1)-receptor immunoreactivity colocalized with alpha-actin within the fibromuscular stroma of the guinea pig prostate. P2X(2)-, P2X(3)- and P2X(4)-receptor immunoreactivity was absent. alphabetamethylene Adenosine 5'-triphosphate (ATP) attenuated contractile responses to electrical field stimulation (50 V, 0.5 ms, 5-20 Hz) in the absence and presence of prazosin (0.3 microM). Responses to 1-2 Hz were unaffected. ARL 67156 (6-N, N-diethyl-beta-gamma-dibromomethylene-D-adenosine-5-triphosphate; 100 microM) enhanced contractile responses to electrical field stimulation (50 V, 0.5 ms, 10-20 Hz). Concentration-response curves to exogenously applied ATP analogues on unstimulated preparations elicited concentration-dependent suramin (100 microM)-sensitive contractions. The rank order of potency was: alphabetamethylene ATP>2methylthio ATP=betagammamethylene ATP>adenosine 5'-diphosphate (ADP)=ATP. Adenosine and adenosine 5'-monophosphate (AMP) did not produce contractile responses. These results demonstrate the presence of functional P2X(1)-receptors within the fibromuscular stroma of the guinea pig prostate and suggest a cotransmitter role for ATP with noradrenaline during high-frequ...Continue Reading

References

Aug 1, 1996·Current Opinion in Neurobiology·G Burnstock, J N Wood
Jan 1, 1997·Annual Review of Medicine·M Barry, C Roehrborn
Feb 15, 1997·The Prostate·K E AnderssonM G Wyllie
Dec 28, 1999·European Journal of Pharmacology·J N PennefatherS Ventura
Nov 9, 2000·Clinical and Experimental Pharmacology & Physiology·S VenturaJ N Pennefather
Jan 5, 2001·British Journal of Pharmacology·B R TuladharR J Naylor
Jan 15, 2002·American Journal of Physiology. Renal Physiology·G E KnightG Burnstock
May 15, 2002·Urology·Karl-Erik Andersson

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Citations

Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Karen P Kerr
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·John M Haynes, Sabatino Ventura
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
Dec 15, 2015·Autonomic Neuroscience : Basic & Clinical·Michelle LamHikaru Hashitani
Jul 29, 2008·European Journal of Pharmacology·Katherine T GraySab Ventura
Jun 3, 2008·The Prostate·Mario GardiPierfrancesco Bassi
Jan 30, 2013·BJU International·Yasemin HocaogluAlexander Roosen
Mar 18, 2011·British Journal of Pharmacology·S VenturaB Exintaris
Apr 22, 2006·Autonomic Neuroscience : Basic & Clinical·Betty ExintarisRichard J Lang
May 20, 2015·Autonomic Neuroscience : Basic & Clinical·George I Gorodeski
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Sep 1, 2017·American Journal of Physiology. Renal Physiology·Annika HerlemannMartin Hennenberg
Jan 12, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Annabel SpekMartin Hennenberg

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