Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart

Journal of Cellular Physiology
Eugene I TikhJames G Dobson

Abstract

Adenosine plays a role in regulating the contractile function of the heart. This includes a positive ionotropic action via the adenosine A(2A) receptor (A(2A)R) and an inhibition of beta(1)-adrenergic receptor-induced ionotropy (antiadrenergic action) via the adenosine A(1) receptor (A(1)R). Phosphatase activity has also been shown to influence contractile function by affecting the level of protein phosphorylation. Protein phosphatase 2A (PP2A) plays a significant role in mediating the A(1)R antiadrenergic effect. The purpose of this study was to investigate the effects of A(2A)R and A(1)R on the activities of PP2A in hearts obtained from wild-type (WT) and A(2A)R knockout (A(2A)R-KO) mice. PP2A activities were examined in myocardial particulate and cytoplasmic extract fractions. Treatment of wild-type hearts with the A(1)R agonist CCPA increased the total PP2A activity and increased the particulate:cytoplasmic PP2A activity ratio. Treatment with the A(2A)R agonist CGS-21680 (CGS) decreased the total PP2A activity and decreased the particulate:cytoplasmic PP2A activity ratio. This indicated a movement of PP2A activity between cell fractions. The effect of CCPA was inhibited by CGS. In A(2A)R-KO hearts the response to A(1)R acti...Continue Reading

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Citations

Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Richard A FentonJames G Dobson
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·John T FassettRobert J Bache
Oct 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·P Charukeshi ChandrasekeraRobert D Lasley
Apr 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Richard A FentonJames G Dobson
Mar 2, 2012·Journal of Cellular Physiology·Richard A Fenton, James G Dobson
Mar 30, 2010·CNS Neuroscience & Therapeutics·K FuxeL F Agnati
Jul 2, 2016·Journal of Neurochemistry·Rodrigo A Cunha
Nov 3, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Walker M McHughTimothy T Cornell
Feb 22, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Victoria J McIntosh, Robert D Lasley
Feb 13, 2021·Frontiers in Pharmacology·P BoknikU Gergs

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